Recombinant Human Interleukin 17C, Fc Chimera
|Product Overview :||Recombinant Human Interleukin 17C is produced in mammalian cells andfused with fused with human IgG1Fc. IL-17C (C-terminus fused with human IgG1Fc) contains 408 amino acids with predicted MW 45.43 kDa x 2 (dimmer) and 14 cysteines (Fc has 6) with no N-link glycosylation site. It stimulates the release of tumor necrosis factor alpha and IL-1beta from the monocytic cell line THP-1.|
- Gene Information
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|Cat. No. :||IL17C-280H|
|Description :||Interleukin-17 (IL-17, or IL-17A) is the founding member of a group of cytokines called the IL-17 family. IL-17A, was originally identified as a transcript from a rodent T-cell hybridoma by Rouvier et al. in 1993. Known as CTLA8 in rodents, IL-17 shows high homology to viral IL-17 encoded by an open reading frame of the T lymphotropic rhadinovirus Herpesvirus saimiri. To elicit its functions, IL-17 binds to a type I cell surface receptor called IL-17R of which there are at least three variants IL17RA, IL17RB, and IL17RC.|
|Source :||Mammalian cells.|
|Quantity :||2.0mg/2ml PBS.|
|Availability :||Back order, one month for production.|
|Gene Name :||IL17C interleukin 17C [ Homo sapiens ]|
|Synonyms :||IL17C; interleukin 17C; CX2; IL-21; IL-17C; MGC126884; MGC138401; interleukin-17C; cytokine CX2|
|Gene ID :||27189|
|mRNA Refseq :||NM_013278|
|Protein Refseq :||NP_037410|
|UniProt ID :||Q9P0M4|
|Chromosome Location :||16q24|
|Function :||cytokine activity|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Animal models, patient biopsies, and genetic association studies reveal IL17C's role in autoimmune diseases.
Combination cytokine stimulation assays and signaling pathway inhibitors elucidate IL17C's crosstalk.
Xenograft models and tumor growth measurements uncover IL17C's contribution to cancer progression.
Flow cytometry analysis with cell-specific markers characterizes IL17C's impact on immune cell subsets.
Neutralizing antibodies and RNA interference validate IL17C's potential as a therapeutic target.
Infection models, bacterial challenges, and mucosal sampling assess IL17C's role in host defense.
Chemotaxis assays and confocal microscopy study IL17C-mediated immune cell recruitment.
Organoid culture systems and cytokine measurements explore IL17C's impact on epithelial barrier function.
Co-immunoprecipitation and mass spectrometry identify IL17C interactors and signaling molecules.
Comparative functional assays and gene knockout models distinguish IL17C's unique roles.
Customer Reviews (3)Write a review
High purity levels. -
Potent in anti-fungal assays. -
Suitable for receptor binding studies. -
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