Recombinant Human Interleukin 17C, Fc Chimera

• Cat.No.: IL17C-280H
• Product Overview: Recombinant Human Interleukin 17C is produced in mammalian cells andfused with fused with human IgG1Fc. IL-17C (C-terminus fused with human IgG1Fc) contains 408 amino acids with predicted MW 45.43 kDa x 2 (dimmer) and 14 cysteines (Fc has 6) with no N-link glycosylation site. It stimulates the release of tumor necrosis factor alpha and IL-1beta from the monocytic cell line THP-1.

Specification

• Cat. No.: IL17C-280H
• Description: Interleukin-17 (IL-17, or IL-17A) is the founding member of a group of cytokines called the IL-17 family. IL-17A, was originally identified as a transcript from a rodent T-cell hybridoma by Rouvier et al. in 1993. Known as CTLA8 in rodents, IL-17 shows high homology to viral IL-17 encoded by an open reading frame of the T lymphotropic rhadinovirus Herpesvirus saimiri. To elicit its functions, IL-17 binds to a type I cell surface receptor called IL-17R of which there are at least three variants IL17RA, IL17RB, and IL17RC.
• Source: Mammalian cells.
• Purity: >90%.
• Quantity: 2.0mg/2ml PBS.
• Storage: -70°C.

Gene Information

• Gene Name: IL17C interleukin 17C [ Homo sapiens ]
• Synonyms: IL17C; interleukin 17C; CX2; IL-21; IL-17C; MGC126884; MGC138401; interleukin-17C; cytokine CX2
• Gene ID: 27189
• mRNA Refseq: NM_013278
• Protein Refseq: NP_037410
• MIM: 604628
• UniProt ID: Q9P0M4
• Chromosome Location: 16q24
• Function: cytokine activity

Reviews

11/26/2021

High purity levels.

03/26/2021

Potent in anti-fungal assays.

06/07/2020

Suitable for receptor binding studies.

Q&As

How is the involvement of IL17C in autoimmune diseases elucidated using experimental models and patient samples?

Animal models, patient biopsies, and genetic association studies reveal IL17C's role in autoimmune diseases.

Can you explain the experimental designs used to study the crosstalk between IL17C and other cytokines in inflammatory responses?

Combination cytokine stimulation assays and signaling pathway inhibitors elucidate IL17C's crosstalk.

How is the function of IL17C in promoting tumor growth and progression investigated in cancer models?

Xenograft models and tumor growth measurements uncover IL17C's contribution to cancer progression.

How are the effects of IL17C modulation on specific immune cell populations characterized using flow cytometry and cell sorting?

Flow cytometry analysis with cell-specific markers characterizes IL17C's impact on immune cell subsets.

What molecular techniques are utilized to validate the therapeutic potential of targeting IL17C in inflammatory disorders?

Neutralizing antibodies and RNA interference validate IL17C's potential as a therapeutic target.

What approaches are taken to assess the role of IL17C in mucosal immunity and host defense against infections?

Infection models, bacterial challenges, and mucosal sampling assess IL17C's role in host defense.

Could you elaborate on the methods used to study IL17C's contribution to tissue-specific immune cell recruitment?

Chemotaxis assays and confocal microscopy study IL17C-mediated immune cell recruitment.

What strategies are used to explore the impact of IL17C on epithelial barrier integrity and inflammation?

Organoid culture systems and cytokine measurements explore IL17C's impact on epithelial barrier function.

What experimental techniques are employed to investigate the binding partners of IL17C and its downstream signaling pathways?

Co-immunoprecipitation and mass spectrometry identify IL17C interactors and signaling molecules.

How do researchers differentiate the functional roles of IL17C from other IL17 family members in immune responses?

Comparative functional assays and gene knockout models distinguish IL17C's unique roles.