Recombinant Mouse Il17c Protein, Myc/DDK-tagged
|Product Overview :||Purified recombinant protein of mouse full-length interleukin 17C (Il17c), with C-terminal MYC/DDK tag, expressed in HEK293T cells.|
- Gene Information
- Related Products
|Description :||Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NFKB and MAPK pathways. Acts synergically with IL22, TNF and IL1B in inducing antibacterial peptides. May have protective function by maintaining epithelial homeostasis after an inflammatory challenge, such as that caused in the intestine by dextran sulfate sodium in a colitis model. May also promote an inflammatory phenotype, such as skin in a psoriasis model. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases, such as autoimmune encephalitis.|
|Molecular Mass :||22 kDa|
|Purity :||> 80% as determined by SDS-PAGE and Coomassie blue staining|
|Stability :||Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.|
|Storage :||Store at -80 centigrade after receiving vials.|
|Concentration :||>50 μg/mL as determined by microplate BCA method|
|Storage Buffer :||25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.|
|Gene Name :||Il17c interleukin 17C [ Mus musculus (house mouse) ]|
|Official Symbol :||Il17c|
|Synonyms :||IL17C; interleukin 17C; IL-17C; MGC175740|
|Gene ID :||234836|
|mRNA Refseq :||NM_145834|
|Protein Refseq :||NP_665833|
|UniProt ID :||Q8K4C5|
|◆ Recombinant Protein|
|IL17C-358H||Active Recombinant Human IL17C Protein, His-tagged||+Inquiry|
|IL17C-441H||Recombinant Human IL17C Protein (Met1-Val197), HIgG1 Fc-tagged||+Inquiry|
|IL17C-2294H||Recombinant Human IL17C Protein, His-tagged||+Inquiry|
|IL17C-149H||Recombinant Human IL17C protein, His-tagged||+Inquiry|
|IL17C-1274R||Recombinant Rat IL17C protein, His-tagged||+Inquiry|
|IL17C-5243HCL||Recombinant Human IL17C 293 Cell Lysate||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Animal models, patient biopsies, and genetic association studies reveal IL17C's role in autoimmune diseases.
Combination cytokine stimulation assays and signaling pathway inhibitors elucidate IL17C's crosstalk.
Xenograft models and tumor growth measurements uncover IL17C's contribution to cancer progression.
Flow cytometry analysis with cell-specific markers characterizes IL17C's impact on immune cell subsets.
Neutralizing antibodies and RNA interference validate IL17C's potential as a therapeutic target.
Infection models, bacterial challenges, and mucosal sampling assess IL17C's role in host defense.
Chemotaxis assays and confocal microscopy study IL17C-mediated immune cell recruitment.
Organoid culture systems and cytokine measurements explore IL17C's impact on epithelial barrier function.
Co-immunoprecipitation and mass spectrometry identify IL17C interactors and signaling molecules.
Comparative functional assays and gene knockout models distinguish IL17C's unique roles.
Customer Reviews (3)Write a review
High purity levels. -
Potent in anti-fungal assays. -
Suitable for receptor binding studies. -
Ask a Question for All Il17c Products
Required fields are marked with *
My Review for All Il17c Products
Required fields are marked with *