Recombinant Human MMP9, His-tagged

• Cat.No.: MMP9-44H
• Product Overview: Recombinant Human Neutrophil Gelatinase Associated Lipocalin is expressed inE. colihaving a molecular weight of 28.1 kDa fused to an amino terminal hexahistidine tag. The NGAL is purified by proprietary chromatographic techniques.

Specification

• Cat. No.: MMP9-44H
• Description: Recombinant Human Lipocalin-2 also called Neutrophil Gelatinase Associated Lipocalin (NGAL) belongs to a family of lipocans which include 25 proteins (including α1-microglobulin and β-lactoglobulin), which are characterized by their ability to bind small lipophilic substances in their hydrophobic core. They thereby serve as transporters of substances like retinal, biliverdins & prostaglandins. There are indications that NGAL is involved in modulation of the inflammatory response and is found in the plasma of patients after stroke.
• Source: Escherichia Coli.
• Physical Appearance: Sterile Filtered clear solution.
• Purity: Greater than 95% as determined by SDS-PAGE. Single band on Western Blot.
• Formulation: Lipocalin-2 (0.35 mg/ml) is supplied in PBS, 50% glycerol.
• Application: NGAL can be used directly as a positive control in Western blotting, ELISA, immunoprecipitation and other immunological experiments. The biological activity of this product has not yet been tested.
• Storage Conditions: Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

Gene Information

• Gene Name: MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) [ Homo sapiens ]
• Synonyms: matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); GELB; CLG4B; MMP-9; MANDP2; MMP9; matrix metalloproteinase 9; type V collagenase; macrophage gelatinase; matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase, 92kD type IV collagenase); Gelatinase B; 92 kDa type IV collagenase; 92 kDa gelatinase; OTTHUMP00000031674; EC 3.4.24.35
• Gene ID: 4318
• mRNA Refseq: NM_004994
• Protein Refseq: NP_004985
• MIM: 120361
• UniProt ID: P14780
• Pathway: Leukocyte transendothelial migration; Pathways in cancer; Bladder cancer
• Function: metalloendopeptidase activity; calcium ion binding; collagen binding; peptidase activity; zinc ion binding

Reviews

05/03/2020

The superior quality of this recombined protein has significantly enhanced the precision of our research outcomes.

08/15/2019

Fast shipping! Ordered this product, and it arrived well-packaged and ready for use in our experiments.

01/21/2018

Customer service went above and beyond to accommodate our specific needs, ensuring a smooth purchasing experience.

Q&As

What are the consequences of dysregulated MMP9 expression in cancer progression?

Dysregulated MMP9 expression is associated with cancer invasion and metastasis, as it enables tumor cells to degrade the extracellular matrix and invade surrounding tissues.

What is the impact of MMP9 polymorphisms on enzyme activity?

Polymorphisms in the MMP9 gene can influence enzyme activity, potentially affecting the individual's susceptibility to certain diseases and the progression of pathological conditions.

Can you explain the role of MMP9 in tissue remodeling at the molecular level?

MMP9 facilitates tissue remodeling by cleaving structural proteins in the extracellular matrix, such as collagen and gelatin, leading to changes in tissue architecture.

What is the role of MMP9 in the breakdown of the blood-brain barrier during neurological disorders?

MMP9 contributes to the breakdown of the blood-brain barrier by degrading tight junction proteins, potentially exacerbating neurological disorders and neuroinflammation.

How does MMP9 contribute to angiogenesis at the molecular level?

MMP9 plays a role in angiogenesis by promoting the release and activation of growth factors sequestered in the extracellular matrix, facilitating the formation of new blood vessels.