Active Recombinant Cynomolgus Monkey MMP9 Protein (Ala20-Asp707)
Cat.No. : | MMP9-13C |
Product Overview : | Recombinant Cynomolgus Monkey MMP9 Protein (Ala20-Asp707) without tag was expressed in Chinese Hamster Ovary cell line. |
- Specification
- Gene Information
- Related Products
Description : | Matrix metalloproteinase 9 (MMP-9), also known as gelatinase B, is a member of the MMP zinc-dependent family of endopeptidases. It cleaves and degrades a variety of targets including important extracellular matrix (ECM) proteins: gelatin, collagen, and elastin, as well as chemokines and extracellular domain plasma membrane proteins. MMP-9 is synthesized and secreted by several cells including neutrophils, macrophages, fibroblasts, and endothelial cells. The monomeric MMP-9 protein is composed of several distinct domains including a signal sequence, a pro-domain which is cleaved upon activation, and a catalytic domain at the n-terminus followed by a hinge region and the c-terminal hemopexin-like domains that contribute to substrate recognition and specificity. The catalytic domain contains fibronectin type II domains, an active site, and a zinc binding site. MMP-9 can exist as a monomer, disulfide-linked homodimer, or heterodimer in complex with lipocalin-2. MMP-9 activity is regulated at several levels via transcription, post-transcription, translation, secretion, activation, and inhibition. As MMP-9 is involved in ECM remodeling and membrane protein cleavage, it has been widely associated to play a role in several diseases including cancers, autoimmune, and cardiovascular diseases. MMP-9 is consequently an important target of interest for inhibition. Additionally, it has been found to be a potential biomarker for many types of cancer including pancreatic, osteosarcoma, lung, ovarian, and breast. |
Source : | CHO |
Species : | Cynomolgus Monkey |
Form : | Proform |
Bio-activity : | Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2. The specific activity is >750 pmol/min/μg. |
Molecular Mass : | Predicted Molecular Mass: 76 kDa SDS-PAGE: 83-95 kDa, under reducing conditions |
N-terminal Sequence Analysis : | Ala20 |
Endotoxin : | <0.10 EU/μg of the protein by the LAL method. |
Purity : | >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 centigrade as supplied. 3 months, -20 to -70 centigrade under sterile conditions after opening. |
Storage Buffer : | Supplied as a 0.2 μm filtered solution in Tris, CaCl2, NaCl and Brij-35. |
Shipping : | The product is shipped with dry ice or equivalent. |
Gene Name : | MMP9 matrix metallopeptidase 9 [ Macaca fascicularis (crab-eating macaque) ] |
Official Symbol : | MMP9 matrix metallopeptidase 9 [ Macaca fascicularis (crab-eating macaque) ] |
Synonyms : | MMP9; matrix metallopeptidase 9; matrix metalloproteinase-9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
Gene ID : | 102117693 |
mRNA Refseq : | XM_005569214 |
Protein Refseq : | XP_005569271 |
Products Types
◆ Recombinant Protein | ||
MMP9-03H | Active Recombinant Pre-activated Human MMP9 Protein | +Inquiry |
MMP9-801H | Recombinant Human MMP9 Protein, His-tagged | +Inquiry |
MMP9-1421H | Recombinant Human MMP9 Protein, His (Fc)-Avi-tagged | +Inquiry |
MMP9-1129H | Recombinant Human MMP9 Protein, His-tagged | +Inquiry |
Mmp9-1132M | Recombinant Mouse Mmp9 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
MMP9-30035TH | Native Human MMP9 | +Inquiry |
MMP9-41H | Native Human MMP-9/TIMP-1 Complex | +Inquiry |
MMP9-39H | Native Human MMP-9/Lipocalin Complex | +Inquiry |
◆ Lysates | ||
MMP9-2560HCL | Recombinant Human MMP9 cell lysate | +Inquiry |
MMP9-1940RCL | Recombinant Rat MMP9 cell lysate | +Inquiry |
MMP9-2026MCL | Recombinant Mouse MMP9 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-3100 | MMP-9 Fluorimetric Assay Kit | +Inquiry |
Kit-2130 | MMP-9 Inhibitor Screening Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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