Recombinant Human MOG Protein, C-6×His-tagged

• Cat.No.: MOG-063H
• Product Overview: Recombinant human MOG protein with C-6×His tag was expressed in E. coli.

Specification

• Description: The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Source: E. coli
• Species: Human
• Tag: His
• Form: lyophilized
• Molecular Mass: 15.2 kDa
• Protein length: 247
• AA Sequence: MASLSRPSLPSCLCSFLLLLLLQVS SSYAGQFRVIGPRHPIRALVGDEVE LPCRISPGKNATGMEVGWYRPPFSR VVHLYRNGKDQDGDQAPEYRGRTEL LKDAIGEGKVTLRIRNVRFSDEGGF TCFFRDHSYQEEAAMELKVEDPFYW VSPGVLVLLAVLPVLLLQITVGLIF LCLQYRLRGKLRAEIENLHRTFDPH FLRVPCWKITLFVIVPVLGPLVALI ICYNWLHRRLAGQFLEELRNPF
• Purity: > 95%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: 4°C
• Concentration: 1 mg/mL
• Storage Buffer: Sodium-acetate (pH 4). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: MOG myelin oligodendrocyte glycoprotein [ Homo sapiens (human) ]
• Official Symbol: MOG
• Synonyms: MOG; myelin oligodendrocyte glycoprotein; myelin-oligodendrocyte glycoprotein; MOG Ig-AluB; MOG alpha-5; MOGIG2; NRCLP7; MGC26137
• Gene ID: 4340
• mRNA Refseq: NM_001008228
• Protein Refseq: NP_001008229
• MIM: 159465
• UniProt ID: Q16653

Reviews

11/20/2022

Excellent in protein studies.

03/14/2022

Reliable, efficient, and effective.

11/23/2021

Worked well, great quality.

Q&As

In which cells or tissues is MOG predominantly expressed?

MOG is predominantly expressed on the outer surface of the myelin sheath in the central nervous system.

What role does MOG play in autoimmune demyelinating diseases?

MOG is a target in autoimmune demyelinating diseases, where the immune system mistakenly attacks it, damaging the myelin sheath.

What diagnostic or therapeutic strategies involve MOG in the context of demyelinating diseases?

MOG antibody testing helps diagnose and distinguish different demyelinating diseases, and therapies aim to modulate the immune response to prevent MOG attack.

Are there known genetic mutations or alterations in MOG associated with specific neurological conditions?

There are no widely recognized genetic mutations in MOG associated with neurological conditions, but research is ongoing.

How does MOG contribute to the integrity and function of the myelin sheath?

MOG contributes to myelin integrity, aiding in proper nerve signal transmission.

How is MOG implicated in the pathogenesis of Multiple Sclerosis (MS)?

MOG antibodies are found in a subset of MS patients, but their exact role in MS pathogenesis is still under investigation.

What is the primary function of MOG in the nervous system?

MOG is involved in the maintenance and stability of the myelin sheath in the central nervous system.