Native Mouse/Rat MOG (35-55) Protein

• Cat.No.: MOG-20
• Product Overview: Purified myelin oligodendrocyte glycoprotein (MOG) for MOG-induced EAE models in mouse and rat.

Specification

• Description: Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). The main characteristics of the disease are focal areas of demyelination and inflammation, however the pathogenesis is unclear. Although no animal model thus far establishes all facets of human MS, Experimental Autoimmune Encephalomyelitis (EAE) represents the model most studied for the disease. Initially brain homogenates were used as antigens for immunization. Today, myelin related proteins or peptides are used in the disease.
• Species: Mouse/Rat
• Form: Lyophilized, 25 mg/vial
• Molecular Mass: 2581.96
• Purity: ≥ 96% (HPLC)
• Applications: Multiple Sclerosis: MOG 35-55 induced experimental autoimmune encephalomyelitis (EAE) rodent models.
• Storage: Storage at -20 centigrade.
• Shipping: Shipping at ambient temperature.
• Official Symbol: MOG
• Synonyms: myelin oligodendrocyte glycoprotein; MOG

Gene Information

• Official Symbol: MOG
• Synonyms: myelin oligodendrocyte glycoprotein; MOG

Reviews

11/20/2022

Excellent in protein studies.

03/14/2022

Reliable, efficient, and effective.

11/23/2021

Worked well, great quality.

Q&As

In which cells or tissues is MOG predominantly expressed?

MOG is predominantly expressed on the outer surface of the myelin sheath in the central nervous system.

What role does MOG play in autoimmune demyelinating diseases?

MOG is a target in autoimmune demyelinating diseases, where the immune system mistakenly attacks it, damaging the myelin sheath.

What diagnostic or therapeutic strategies involve MOG in the context of demyelinating diseases?

MOG antibody testing helps diagnose and distinguish different demyelinating diseases, and therapies aim to modulate the immune response to prevent MOG attack.

Are there known genetic mutations or alterations in MOG associated with specific neurological conditions?

There are no widely recognized genetic mutations in MOG associated with neurological conditions, but research is ongoing.

How does MOG contribute to the integrity and function of the myelin sheath?

MOG contributes to myelin integrity, aiding in proper nerve signal transmission.

How is MOG implicated in the pathogenesis of Multiple Sclerosis (MS)?

MOG antibodies are found in a subset of MS patients, but their exact role in MS pathogenesis is still under investigation.

What is the primary function of MOG in the nervous system?

MOG is involved in the maintenance and stability of the myelin sheath in the central nervous system.