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Recombinant Human NRG1, His-tagged

Cat.No. : NRG1-27577TH
Product Overview : Recombinant fragment, corresponding to amino acids 177-237 of Human NRG1 and an additional N terminal Arginine with His tag produced in the endosperm tissue of barley grain ; 62 amino acids , 13 kDa.
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Description : The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD).
Conjugation : HIS
Tissue specificity : Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stom
Biological activity : Bioactivity:Bioactivity is assayed by measuring the dose dependent effect of Human NRG1 on proliferation of MCF7 cells. ED50 is calculated from the effect of serial dilutions on cell proliferation. The ED50 for this batch is 2.9 ng/ml according to this as
Form : Lyophilised:It is recommended to reconstitute the lyophilized protein in sterile phosphate-buffered saline to a concentration of no less than 100 μg/ml. For long term storage of the reconstituted solution it is recommended to add a carrier protein (0.1% H
Storage buffer : Preservative: NoneConstituents: PBS, pH 7.2
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the neuregulin family.Contains 1 EGF-like domain.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Gene Name : NRG1 neuregulin 1 [ Homo sapiens ]
Official Symbol : NRG1
Synonyms : NRG1; neuregulin 1; HGL; pro-neuregulin-1, membrane-bound isoform; GGF; HRG; NDF;
Gene ID : 3084
mRNA Refseq : NM_001159995
Protein Refseq : NP_001153467
MIM : 142445
Uniprot ID : Q02297
Chromosome Location : 8p21-p12
Pathway : ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; Glypican 1 network, organism-specific biosystem; MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem;
Function : ErbB-3 class receptor binding; ErbB-3 class receptor binding; cytokine activity; growth factor activity; growth factor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is NRG1 implicated in neural development and synaptic plasticity? 06/09/2022

NRG1 is essential for neural development, influencing neuronal migration, myelination, and synapse formation. It also plays a role in synaptic plasticity, modulating neurotransmission and synaptic strength.

What role does NRG1 play in cardiac development and function? 12/01/2019

In the heart, NRG1 is involved in the regulation of cardiac development, including trabeculation. It also has protective effects on cardiac muscle cells and can influence heart repair mechanisms.

Are there any associations between NRG1 mutations or dysregulation and diseases? 01/15/2019

Dysregulation of NRG1 signaling has been implicated in several diseases, including schizophrenia, multiple sclerosis, and certain types of cancers. Genetic variations in the NRG1 gene have been associated with increased risk for some of these conditions.

What are the therapeutic implications of targeting NRG1 in various diseases? 09/18/2018

Given the diverse roles of NRG1 in various physiological processes, it presents as a potential therapeutic target. For instance, recombinant NRG1 has been explored for heart failure treatment, and its modulation is being studied in the context of neural disorders and cancers.

Are there different isoforms of NRG1, and how do they differ in function? 05/29/2018

Yes, there are multiple isoforms of NRG1, generated through alternative splicing. These isoforms can differ in their tissue distribution, receptor binding, and functional roles.

How does NRG1 interact with its receptor, and what are the downstream signaling pathways activated? 03/17/2018

NRG1 primarily interacts with the ErbB family of tyrosine kinase receptors, especially ErbB3 and ErbB4. Upon binding, it activates downstream pathways such as the PI3K/Akt and MAPK pathways.

What is the primary biological function of the NRG1 protein? 02/16/2018

NRG1 is a versatile signaling molecule that plays crucial roles in the development and function of multiple organ systems, including the nervous system, heart, and breast.

Customer Reviews (3)

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Reviews
08/12/2022

    Excellent results, very consistent.

    01/27/2021

      Worked great in assays.

      01/02/2019

        Great product, very reliable.

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