Recombinant Human NRG1, His-tagged
Cat.No. : | NRG1-27577TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 177-237 of Human NRG1 and an additional N terminal Arginine with His tag produced in the endosperm tissue of barley grain ; 62 amino acids , 13 kDa. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). |
Conjugation : | HIS |
Tissue specificity : | Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stom |
Biological activity : | Bioactivity:Bioactivity is assayed by measuring the dose dependent effect of Human NRG1 on proliferation of MCF7 cells. ED50 is calculated from the effect of serial dilutions on cell proliferation. The ED50 for this batch is 2.9 ng/ml according to this as |
Form : | Lyophilised:It is recommended to reconstitute the lyophilized protein in sterile phosphate-buffered saline to a concentration of no less than 100 μg/ml. For long term storage of the reconstituted solution it is recommended to add a carrier protein (0.1% H |
Storage buffer : | Preservative: NoneConstituents: PBS, pH 7.2 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the neuregulin family.Contains 1 EGF-like domain.Contains 1 Ig-like C2-type (immunoglobulin-like) domain. |
Gene Name : | NRG1 neuregulin 1 [ Homo sapiens ] |
Official Symbol : | NRG1 |
Synonyms : | NRG1; neuregulin 1; HGL; pro-neuregulin-1, membrane-bound isoform; GGF; HRG; NDF; |
Gene ID : | 3084 |
mRNA Refseq : | NM_001159995 |
Protein Refseq : | NP_001153467 |
MIM : | 142445 |
Uniprot ID : | Q02297 |
Chromosome Location : | 8p21-p12 |
Pathway : | ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; Glypican 1 network, organism-specific biosystem; MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; |
Function : | ErbB-3 class receptor binding; ErbB-3 class receptor binding; cytokine activity; growth factor activity; growth factor activity; |
Products Types
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Nrg1-6199M | Recombinant Mouse Nrg1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NRG1-142H | Recombinant Human NRG1 Protein (Ser20-Lys241), Animal-free, Carrier-free | +Inquiry |
NRG1-29H | Recombinant Human/Bovine/Porcine NRG1 Protein | +Inquiry |
NRG1-23M | Active Recombinant Mouse Nrg1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
NRG1-001CCL | Recombinant Canine NRG1 cell lysate | +Inquiry |
NRG1-836CCL | Recombinant Canine NRG1 cell lysate | +Inquiry |
NRG1-1599HCL | Recombinant Human NRG1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionNRG1 is essential for neural development, influencing neuronal migration, myelination, and synapse formation. It also plays a role in synaptic plasticity, modulating neurotransmission and synaptic strength.
In the heart, NRG1 is involved in the regulation of cardiac development, including trabeculation. It also has protective effects on cardiac muscle cells and can influence heart repair mechanisms.
Dysregulation of NRG1 signaling has been implicated in several diseases, including schizophrenia, multiple sclerosis, and certain types of cancers. Genetic variations in the NRG1 gene have been associated with increased risk for some of these conditions.
Given the diverse roles of NRG1 in various physiological processes, it presents as a potential therapeutic target. For instance, recombinant NRG1 has been explored for heart failure treatment, and its modulation is being studied in the context of neural disorders and cancers.
Yes, there are multiple isoforms of NRG1, generated through alternative splicing. These isoforms can differ in their tissue distribution, receptor binding, and functional roles.
NRG1 primarily interacts with the ErbB family of tyrosine kinase receptors, especially ErbB3 and ErbB4. Upon binding, it activates downstream pathways such as the PI3K/Akt and MAPK pathways.
NRG1 is a versatile signaling molecule that plays crucial roles in the development and function of multiple organ systems, including the nervous system, heart, and breast.
Customer Reviews (3)
Write a reviewExcellent results, very consistent.
Worked great in assays.
Great product, very reliable.
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