Recombinant Human/Bovine/Porcine NRG1 Protein

• Cat.No.: NRG1-29H
• Product Overview: Recombinant human/bovine/porcine NRG-1 protein without tag was expressed in E. coli.
  Animal-free (AOF) and carrier protein-free.
  Mass spectrometry: single species with expected mass.
  Analytical reversed-phase: single sharp peak.
  Recovery from stock vial: >95%

Specification

• Description: The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).
• Source: E. coli
• Species: Human
• Molecular Mass: 7.5 kDa
• Endotoxin: <0.005 EU/μg protein (below level of detection)
• Applications: Maintenance of pluripotency in human iPSC; cell culture media optimisation and replacement of insulin in defined media
• Storage: Resuspend in water at >100 μg/mL, prepare single use aliquots, add carrier protein if desired and store frozen at -20 or -80 centigrade
• Storage Buffer: Lyophilized from acetonitrile, TFA

Gene Information

• Gene Name: NRG1 neuregulin 1 [ Homo sapiens (human) ]
• Official Symbol: NRG1
• Synonyms: NRG1; neuregulin 1; GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; MSTP131; NRG1-IT2; pro-neuregulin-1, membrane-bound isoform; acetylcholine receptor-inducing activity; glial growth factor 2; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; pro-NRG1; sensory and motor neuron derived factor
• Gene ID: 3084
• mRNA Refseq: NM_013960
• Protein Refseq: NP_039254
• MIM: 142445
• UniProt ID: Q02297