Recombinant Human PSEN2 Over expression Lysate, C-Myc/DDK-tagged

• Cat.No.: PSEN2-HCL
• Product Overview: Recombinant Human PSEN2 Over expression Lysate with C-Myc/DDK-tag was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
• Molecular Mass: 50.1 kDa
• Storage: Upon receiving, store the sample at -20 centigrade. Avoid repeated freeze-thaw cycles after reconstitution. Lysate samples are stable for 12 months from date of receipt when stored at -20 centigrade.
• Reconstitution: Lysate samples can be reconstituted with SDS Sample Buffer.
• Shipping: The lysate can be shipped at ambient temperature.

Gene Information

• Gene Name: PSEN2 presenilin 2 [ Homo sapiens (human) ]
• Official Symbol: PSEN2
• Synonyms: PSEN2; presenilin 2; AD4; PS2; AD3L; STM2; CMD1V; presenilin-2; AD3LP; AD5; Alzheimer disease 3-like; Alzheimer disease 4; E5-1; PS-2; STM-2; EC 3.4.23.-
• Gene ID: 5664
• mRNA Refseq: NM_012486
• Protein Refseq: NP_036618
• MIM: 600759
• UniProt ID: P49810