Species : |
Human |
Source : |
HEK293 |
Tag : |
DDK&Myc |
Description : |
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. |
Molecular Mass : |
50.1 kDa |
Storage : |
Upon receiving, store the sample at -20 centigrade. Avoid repeated freeze-thaw cycles after reconstitution. Lysate samples are stable for 12 months from date of receipt when stored at -20 centigrade. |
Reconstitution : |
Lysate samples can be reconstituted with SDS Sample Buffer. |
Shipping : |
The lysate can be shipped at ambient temperature. |