Recombinant Human SRC, GST-tagged, Active

• Cat.No.: SRC-433H
• Product Overview: Recombinant full-length Rous sarcoma virus SRC was expressed by baculovirus inSf9insect cells using a N-terminal GST tag. MW = 85 kDa.

Specification

• Cat. No.: SRC-433H
• Description: SRC family belongs to non-receptor tyrosine kinases. SRC was originally identified as a transforming protein of the Rous sarcoma virus (RSV) that had enzymatic ability to phosphorylate tyrosine in protein substrates. SRC is overexpressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases. In addition to increasing cell proliferation, a key role of SRC in cancer seems to be the ability to promote invasion and motility, functions that might contribute to tumour progression.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [ Homo sapiens ]
• Synonyms: SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); ASV; SRC1; c-SRC; p60-Src; proto-oncogene tyrosine-protein kinase SRC; OTTHUMP00000174476; OTTHUMP00000174477; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; EC 2.7.10.2; pp60c-src; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
• Gene ID: 6714
• mRNA Refseq: NM_005417
• Protein Refseq: NP_005408
• MIM: 190090
• UniProt ID: P12931
• Chromosome Location: 20q12-q13
• Pathway: Adherens junction; Endocytosis; Epithelial cell signaling in Helicobacter pylori infection; ErbB signaling pathway; Focal adhesion; Gap junction; GnRH signaling pathway; Tight junction; VEGF signaling pathway
• Function: ATP binding; SH2 domain binding; SH3/SH2 adaptor activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; transferase activity

Reviews

01/01/2022

Top-notch protein purification service, essential for our research.

08/29/2019

Reliable mass spectrometry analysis, pivotal for our proteomics work.

03/02/2019

Swift and reliable protein sequencing, indispensable for our research success.

Q&As

How do alterations in SRC expression or activity affect the development of drug resistance in tumors?

Changes in SRC expression or kinase activity can lead to drug resistance in cancer treatment.

How does SRC (proto-oncogene tyrosine-protein kinase Src) regulate cell proliferation and survival?

SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.

How does SRC contribute to the regulation of bone remodeling and osteoclast activity?

SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.

What role does SRC play in cancer development and progression, particularly in metastasis?

SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.

How does SRC influence cellular signaling pathways, such as the Ras/MAPK and PI3K/Akt pathways?

SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.

What are the mechanisms by which SRC modulates cellular adhesion and migration?

SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.

What is the impact of SRC inhibition on targeted cancer therapies?

SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.