Recombinant Mouse Abi2 Protein, Myc/DDK-tagged

Cat.No. : Abi2-1475M
Product Overview : Purified recombinant protein of mouse full-length abl-interactor 2 (Abi2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation. Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge. Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain. In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth. Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface. Also required for nascent adherens junction assembly in epithelial cells.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 49.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Abi2 abl interactor 2 [ Mus musculus (house mouse) ]
Official Symbol : Abi2
Synonyms : Abi2; abl interactor 2; AblBP3; ArgBP1; AI839867; C130078H13; 8430425M24Rik; abl interactor 2; abelson interactor 2; abi-2; abl-binding protein 3; arg-binding protein 1
Gene ID : 329165
mRNA Refseq : NM_198127
Protein Refseq : NP_937760
UniProt ID : P62484

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Q&As (5)

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Can you provide ABI2 proteins from species other than humans and mice? 04/14/2023

Yes, our experts can customize protein expression according to your research needs.

Why does your ABI2 protein use His or GST tags? 04/14/2023

His and GST tags are commonly used for affinity chromatography and are beneficial for improving protein solubility.

What diseases is ABI2 associated with? 04/14/2023

Disease variant and intellectual disability.

What biological processes is ABI2 involved in? 04/14/2023

It is involved in host-virus interactions and neurogenesis.

Do you have anti-ABI2 primary antibodies? 04/14/2023

Creative BioMart mainly provides custom protein services, and you can consult our scientists for specific project requirements.

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