| Description : |
The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. |
| Source : |
E. coli |
| Species : |
Mouse |
| Tag : |
His |
| Form : |
Liquid |
| Molecular Mass : |
27.6 kDa |
| Protein length : |
19-239 |
| AA Sequence : |
MGSSHHHHHHSSGLVPRGSHMGSHM FTITAPKDLYVVEYGSNVTMECRFP VERELDLLALVVYWEKEDEQVIQFV AGEEDLKPQHSNFRGRASLPKDQLL KGNAALQITDVKLQDAGVYCCIISY GGADYKRITLKVNAPYRKINQRISV DPATSEHELICQAEGYPEAEVIWTN SDHQPVSGKRSVTTSRTEGMLLNVT SSLRVNATANDVFYCTFWRSQPGQN HTAELIIPELPATHPPQNRTH |
| Purity : |
> 85 % by SDS-PAGE |
| Stability : |
Shelf life: one year from despatch. |
| Storage : |
Store undiluted at 2-8 centigrade for one week or (in aliquots) at -20 to -80 centigrade for longer. Avoid repeated freezing and thawing. |
| Concentration : |
1.0 mg/mL (determined by Bradford assay) |
| Storage Buffer : |
20 mM Tris-HCl buffer (pH 8.0) containing 10 % glycerol, 0.15 M NaCl |
