Recombinant Mouse FLT3 protein, His-tagged
Cat.No. : | FLT3-1456M |
Product Overview : | Recombinant Mouse FLT3 protein(Asn28-Ser544), fused with His tag, was expressed in HEK293. |
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Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. |
Molecular Mass : | This protein carries a polyhistidine tag at the C-terminus.The protein has a calculated MW of 59.9 kDa. The protein migrates as 70-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Proteinlength : | Asn28-Ser544 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >90% as determined by SDS-PAGE. |
Storage : | For long term, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Protein length : | Asn28-Ser544 |
Gene Name : | Flt3 FMS-like tyrosine kinase 3 [ Mus musculus ] |
Official Symbol : | FLT3 |
Synonyms : | FLT3; FMS-like tyrosine kinase 3; receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; fetal liver kinase 2; tyrosine-protein kinase FLT3; tyrosine-protein kinase receptor flk-2; Flk2; Ly72; wmfl; CD135; Flk-2; Flt-3; B230315G04; MGC124377; MGC124378; |
Gene ID : | 14255 |
mRNA Refseq : | NM_010229 |
Protein Refseq : | NP_034359 |
Products Types
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◆ Lysates | ||
FLT3-970MCL | Recombinant Mouse FLT3 cell lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewExcellent product, great price.
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Q&As (7)
Ask a questionFLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.
FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.
It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.
Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.
FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.
It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.
Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.
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