| Description : |
This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. |
| Source : |
E. coli |
| Species : |
Mouse |
| Bio-activity : |
Measured by its ability to induce IL-6 production by NIH 3T3 cells. |
| Molecular Mass : |
30 kDa |
| AA Sequence : |
AAIIPQSSACPNTEAKDFLQNVKVN LKVFNSLGAKVSSRRPSDYLNRSTS PWTLHRNEDPDRYPSVIWEAQCRHQ RCVNAEGKLDHHMNSVLIQQEILVL KREPESCPFTFRVEKMLVGVGCTCV ASIVRQAA |
| Endotoxin : |
Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
| Purity : |
>95%, as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. |
| Storage Buffer : |
Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2 |
| Reconstitution : |
Resuspend the protein in the desired concentration in proper buffer. |
