| Description : |
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. |
| Source : |
E. coli |
| Species : |
Mouse |
| Bio-activity : |
The ED50 is 15 - 60 ng/mL, corresponding to a specific activity of 1.7 - 6.7 × 10^4 units/mg. |
| Molecular Mass : |
14.2 kDa |
| Protein length : |
Pro25-Ser146 |
| Endotoxin : |
Less than 0.01 ng/μg protein as determined by the LAL method |
| Purity : |
> 98%, as determined by Coomassie stained SDS-PAGE. |
| Stability : |
Unopened vial can be stored between 2 and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
Protein formulated and vialed at >50 μg/mL in specified buffer |
| Storage Buffer : |
1 x PBS |
