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Active Recombinant Mouse Il21 Protein, His-Tagged

Cat.No. : Il21-01M
Product Overview : Recombinant mouse Il21 Protein, His-tagged was expressed in E. coli cell
  • Specification
  • Gene Information
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Description : Interleukin-21 (IL21) belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Interleukin-21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. This cytokine induces cell division/proliferation in its target cells.
Source : Escherichia coli
Species : Mouse
Tag : His
Form : Lyophilized powder
AA Sequence : MHKSSPQGPDRLLIRLRHLIDIVEQ LKIYENDLDPELLSAPQDVKGHCEH AAFACFQKAKLKPSNPGNNKTFIID LVAQLRRRLPARRGGKKQ
KHIAKCPSCDSYEKRTPKEFLERLK WLLQKMIHQHLS with polyhistidine tag at the C-terminus
Endotoxin : <0.1 EU per 1 μg of the protein by the LAL method.
Bio-activity : Measure by its ability to enhance IFN gamma secretion in NK-92 cells. The ED50 for this effect is <6 ng/mL. The specific activity of recombinant mouse IL-21 is > 1.6 x 10^5 IU/mg.
Purity : >95% as determined by SDS-PAGE. Ni-NTA chromatography
Storage Buffer : The protein was lyophilized from a solution containing 1X PBS, pH 7.4.
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Storage : Lyophilized protein should be stored at -20°C. Upon reconstitution, protein aliquots should be stored at -20°C or -80°C.
Notes : Please use within one month after protein reconstitution.
Gene Name : Il21 interleukin 21 [ Mus musculus (house mouse) ]
Official Symbol : Il21
Synonyms : IL-21
Gene ID : 60505
mRNA Refseq : NM_001291041.1
Protein Refseq : NP_001277970.1
UniProt ID : A0A8C6GYE7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In which types of cancer has IL21 protein shown promising results? 02/17/2023

IL21 has demonstrated efficacy in preclinical and clinical studies for various cancers, including melanoma, renal cell carcinoma, and lymphoma.

Are there any side effects associated with IL21 therapy? 11/12/2021

Common side effects may include fatigue, fever, and flu-like symptoms. However, the severity and type of side effects can vary among individuals.

Can IL21 be used as a standalone treatment for cancer? 09/17/2021

IL21 is often investigated in combination with other cancer therapies to enhance its effectiveness, and it has shown promise in combination treatments.

Are there any ongoing clinical trials exploring the use of IL21 in autoimmune conditions? 03/04/2020

Yes, several clinical trials are investigating the efficacy and safety of IL21 in autoimmune diseases, such as rheumatoid arthritis and lupus.

How does IL21 influence the development of memory T cells? 10/29/2018

IL21 promotes the differentiation and survival of memory T cells, contributing to the long-term immune response against pathogens.

Customer Reviews (3)

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Reviews
08/19/2022

    With the IL21 protein at hand, I am excited to embark on my scientific journey with confidence and optimism.

    01/30/2022

      I am confident that incorporating the IL21 protein into my research will yield accurate and reliable results, enabling deeper insights into cellular processes

      04/23/2019

        Their expertise and guidance will undoubtedly prove valuable in overcoming hurdles and maximizing the potential of this protein in my research endeavors.

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