Recombinant Mouse Il23r Protein, Fc-tagged

• Cat.No.: Il23r-327M
• Product Overview: Recombinant Mouse Il23r protein with Fc tag was expressed in HEK293.

Specification

• Description: Predicted to enable cytokine binding activity and interleukin-23 receptor activity. Predicted to contribute to interleukin-12 receptor binding activity and interleukin-23 binding activity. Predicted to be involved in several processes, including positive regulation of defense response to virus by host; regulation of cytokine production; and response to interferon-gamma. Predicted to act upstream of or within leukocyte mediated immunity and receptor signaling pathway via JAK-STAT. Predicted to be integral component of plasma membrane. Predicted to be part of interleukin-23 receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); inflammatory bowel disease (multiple); pulmonary hypertension; rhinitis; and systemic scleroderma. Orthologous to human IL23R (interleukin 23 receptor).
• Source: HEK293
• Species: Mouse
• Tag: Fc
• Form: Lyophilized
• Molecular Mass: 66.8 kDa
• Protein Length: 644
• AA Sequence: MSHLTLQLHVVIALYVLFRWCHGGI TSINCSGDMWVEPGEIFQMGMNVSI YCQEALKHCRPRNLYFYKNGFKEEF DITRINRTTARIWYKGFSEPHAYMH CTAECPGHFQETLICGKDISSGHPP DAPSNLTCVIYEYSGNMTCTWNTGK PTYIDTKYIVHVKSLETEEEQQYLA SSYVKISTDSLQGSRKYLVWVQAVN SLGMENSQQLHVHLDDIVIPSASII SRAETTNDTVPKTIVYWKSKTMIEK VFCEMRYKTTTNQTWSVKEFDANFT YVQQSEFYLEPDSKYVFQVRCQETG KRNWQPWSSPFVHQTSQETGKRNWQ PWSSPFVHQTSQTVSQVTAKSSHEP QKMEMLSATIFRGHPASGNHQDIGL LSGMVFLAIMLPIFSLIGIFNRSLR IGIKRKVLLMIPKWLYEDIPNMENS NVAKLLQEKSVFENDNASEQALYVD PVLTEISEISPLEHKPTDYKEERLT GLLETRDCPLGMLSTSSSVVYIPDL NTGYKPQVSNVPPGGNLFINRDERD PTSLETTDDHFARLKTYPNFQFSAS SMALLNKTLILDELCLVLNQGEFNS LDIKNSRQEETSIVLQSDSPSETIP AQTLLSDEFVSCLAIGNEDLPSINS YFPQNVLESHFSRISLFQK
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: Il23r interleukin 23 receptor [ Mus musculus (house mouse) ]
• Official Symbol: Il23r
• Synonyms: IL23R; interleukin 23 receptor; interleukin-23 receptor; IL-23 receptor; IL-23R
• Gene ID: 209590
• mRNA Refseq: NM_144548
• Protein Refseq: NP_653131
• UniProt ID: Q8K4B4

Reviews

10/21/2020

High specificity in ELISA.

04/28/2016

Effective in autoimmune models.

03/30/2016

Suitable for receptor binding studies.

Q&As

How does IL23R activation affect T-cell differentiation?

IL23R activation promotes Th17 cell differentiation.

Does IL23R have alternative splicing variants?

IL23R has multiple alternative splicing variants.

Does IL23R have any post-translational modifications that affect its stability?

IL23R undergoes phosphorylation that affects its stability.

What is the half-life of IL23R protein in activated T-cells?

The half-life of IL23R protein in activated T-cells is approximately 48 hours.

Are there any microRNAs that regulate IL23R expression?

MicroRNAs like miR-20a regulate IL23R expression.

How does IL23R contribute to cytokine release?

IL23R contributes to the release of pro-inflammatory cytokines like IL-17.

What role does IL23R play in autoimmune diseases?

IL23R is implicated in autoimmune diseases like Crohn's.

How does IL23R expression change during infection?

IL23R expression is upregulated during bacterial infection.

Does IL23R form homodimers or heterodimers?

IL23R forms heterodimers with IL-12Rβ1.

What intracellular pathways are activated by IL23R?

IL23R activates the JAK-STAT and NF-κB pathways.