IL23R
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Official Full Name
interleukin 23 receptor -
Overview
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), -
Synonyms
IL23R;interleukin 23 receptor;interleukin-23 receptor;IL 23R;IL-23 receptor
Recombinant Proteins
- Mouse
- Cynomolgus/Rhesus
- Rat
- Human
- Cynomolgus
- Canine
- Rhesus macaque
- Zebrafish
- Mammalian Cells
- HEK293
- E.coli
- Human Cells
- CHO
- C-His
- Fc
- His
- GST
- Non
- Avi
- mFc
Involved Pathway
IL23R involved in several pathways and played different roles in them. We selected most pathways IL23R participated on our site, such as Cytokine-cytokine receptor interaction,IL23-mediated signaling events,Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL23R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CCR5,BMPR1B,TGFB1,GM10591,TGFB1A,CCL20A.3,CCL21,IFNE,IL10,IL21R |
| Inflammatory bowel disease (IBD) | IL17A,IL1B,IL18R1,NFATC1,HLA-DRB1,TLR5,IL21,RORC,IL13,HLA-DRB4 |
| IL23-mediated signaling events | IL17F,IL24 |
| Jak-STAT signaling pathway | IL12RB1,AOX3,IL21R.1,CSH,GH2,IFNAR2,IRX1,PTPN6,CCND1,IFNA5 |
Protein Function
IL23R has several biochemical functions, for example, contributes_to interleukin-12 receptor binding,contributes_to interleukin-23 binding,contributes_to interleukin-23 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL23R itself. We selected most functions IL23R had, and list some proteins which have the same functions with IL23R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GCC1,HSD17B10,ATF1,BRD8,SPATA8,DZIP1,VEPH1,ANKRD10,DCTN5,TRIM31 |
| contributes_to interleukin-23 binding | IL12RB1 |
| contributes_to interleukin-12 receptor binding | IL12RB1,IL12B |
| contributes_to interleukin-23 receptor activity | IL12RB1 |
Interacting Protein
IL23R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL23R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL23R.
C1D
Resources
Research Area
NeuroinflammationMultiple Sclerosis and Myelin Related Molecules
Negative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
gamma delta T Cells
T Cell Cytokine Signaling
Th17 Cells
IL-12 Family Receptors
Related Services
Related Products
References
- Ciccacci, C; Perricone, C; et al. A Multilocus Genetic Study in a Cohort of Italian SLE Patients Confirms the Association with STAT4 Gene and Describes a New Association with HCP5 Gene. PLOS ONE 9:-(2014).
- Tillack, C; Ehmann, LM; et al. Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-gamma-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment. GUT 63:567-577(2014).
