IL23R
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Official Full Name
interleukin 23 receptor
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Background
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), -
Synonyms
IL23R; interleukin 23 receptor; interleukin-23 receptor; IL 23R; IL-23 receptor;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL23R Related Articles
- IL23R Related Research Area
IL23R involved in several pathways and played different roles in them. We selected most pathways IL23R participated on our site, such as Cytokine-cytokine receptor interaction, IL23-mediated signaling events, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL23R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | BMPR1B;MPL;IL4R;IL12RB1;CCR8;CCL20A.3;TNFRSF13C;TNFRSF1B;CCL19 |
| IL23-mediated signaling events | IL17F;IL24;IL23R |
| Inflammatory bowel disease (IBD) | HLA-DQA2;H2-AB1;STAT4;IL23;Il2;HLA-DPB1;GATA3;HLA-DRA;NFKB1 |
| Jak-STAT signaling pathway | IL24;CSH2;IFNA7;LEPB;PIK3R3A;LEPA;SOS1;TSLP;STAM2 |
IL23R has several biochemical functions, for example, contributes_to interleukin-12 receptor binding, contributes_to interleukin-23 binding, contributes_to interleukin-23 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL23R itself. We selected most functions IL23R had, and list some proteins which have the same functions with IL23R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to interleukin-12 receptor binding | IL12RB1;IL23R;IL12B |
| contributes_to interleukin-23 binding | IL12RB1;IL23R |
| contributes_to interleukin-23 receptor activity | IL23R;IL12RB1 |
| protein binding | SPON1;NAT8B;AKAP7;ZBTB7B;RASGRP3;THRA;PTPN7;FRS2;PEX3 |
IL23R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL23R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL23R.
C1D
- Q&As
- Reviews
Q&As (10)
Ask a questionIL23R activation promotes Th17 cell differentiation.
IL23R has multiple alternative splicing variants.
IL23R undergoes phosphorylation that affects its stability.
The half-life of IL23R protein in activated T-cells is approximately 48 hours.
MicroRNAs like miR-20a regulate IL23R expression.
IL23R contributes to the release of pro-inflammatory cytokines like IL-17.
IL23R is implicated in autoimmune diseases like Crohn's.
IL23R expression is upregulated during bacterial infection.
IL23R forms heterodimers with IL-12Rβ1.
IL23R activates the JAK-STAT and NF-κB pathways.
Customer Reviews (3)
Write a reviewHigh specificity in ELISA. -
Effective in autoimmune models. -
Suitable for receptor binding studies. -
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