• Official Full Name

    interleukin 23 receptor

  • Overview

    The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2),
  • Synonyms

    IL23R; interleukin 23 receptor; interleukin-23 receptor; IL 23R; IL-23 receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Cynomolgus Monkey
  • Cynomolgus/Rhesus
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • hFc
  • His
  • Fc
  • Avi
  • His (Fc)
  • His|GST
  • human|IgG1|Fc
  • mFc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human Il23r-8617H Active Recombinant Human Il23r, HIgG1 Fc-tagged CHO Fc
Human Il23R-8615H Active Recombinant Human Il23R, MIgG2a Fc-tagged CHO Fc
Human IL23R-2400H Recombinant Human IL23R protein(Met1-Asp353), hFc-tagged HEK293 C-hFc Met1-Asp353
Human IL23R-8614H Recombinant Human IL23R protein, Fc-tagged HEK293 human/IgG1/Fc Gly24-Gly355
Human IL23R-1213HCL Recombinant Human IL23R cell lysate Human Cell N/A
Human IL23R-589H Recombinant Human IL23R protein, His-tagged HEK293 His Gly24-Gly355
Human IL23R-3082H Recombinant Human IL23R protein, His-tagged E.coli His 31-130 aa
Human IL23R-614H Recombinant Human IL23R protein, mFc-tagged HEK293 mFc It contains Gly24 - Gly355.
Human IL23R-0273H Active Recombinant Human IL23R protein, Fc-tagged HEK293 Fc Gly24-Gly355
Human IL23R-0272H Active Recombinant Human IL23R protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Gly24-Gly355
Human IL23R-2393H Recombinant Human IL23R protein(Met1-Asp353), His-tagged HEK293 C-His Met1-Asp353
Mouse Il23r-5658M Active Recombinant Mouse Il23r, His-tagged Human Cell His
Mouse Il23r-5657M Active Recombinant Mouse Interleukin 23 Receptor, Fc-tagged Mammalian cells Fc
Mouse Il23r-71M Recombinant Mouse Il23r Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Il23r-327M Recombinant Mouse Il23r Protein, Fc-tagged HEK293 Fc 644
Mouse IL23R-135M Active Recombinant Mouse IL23R protein, His-tagged HEK293 His Gly24-Gly374
Mouse IL23R-348M Active Recombinant Mouse IL23R protein, Fc-tagged HEK293 Fc Gly 24 - Asp 372
Mouse IL23R-0274M Active Recombinant Mouse IL23R protein, Fc-tagged HEK293 Fc Gly24-Asp372
Mouse Il23r-71M-B Recombinant Mouse Il23r Protein Pre-coupled Magnetic Beads HEK293
Rat Il23r-8801R Active Recombinant Rat Il23r protein(Met1-Asp367), hFc-tagged HEK293 C-hFc Met1-Asp367
Rat Il23r-1319R Recombinant Rat Il23r protein, His & GST-tagged E.coli His/GST Ile25~Leu355 (Accession # F1LX96)
Rat IL23R-1110R Recombinant Rat IL23R Protein, His-tagged HEK293 His
Rat IL23R-1234RCL Recombinant Rat IL23R cell lysate Human Cell N/A
Rat Il23r-1030R Recombinant Rat Il23r Protein, His-tagged HEK293F N-His Ile25-Leu355
Cynomolgus IL23R-0271C Active Recombinant Cynomolgus IL23R protein, Fc-tagged HEK293 Fc Gly24-Asp353
Cynomolgus Monkey IL23R-1429CCL Recombinant Cynomolgus IL23R cell lysate Human Cell N/A
Cynomolgus/Rhesus IL23R-8493C Active Recombinant Cynomolgus/Rhesus IL23R protein, hFc-tagged HEK293 hFc Met1-Asp353
Rhesus Macaque IL23R-804R Active Recombinant Rhesus Macaque IL23R protein, hFc-tagged HEK293 hFc Met1-Asp353
Zebrafish IL23R-6305Z Recombinant Zebrafish IL23R Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL23R involved in several pathways and played different roles in them. We selected most pathways IL23R participated on our site, such as Cytokine-cytokine receptor interaction, IL23-mediated signaling events, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL23R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCXCR1;KIT;ACVR2AA;TNFSF9;CXCL12;CCR9A;CCL2;CXCL2;IL1RAP
IL23-mediated signaling eventsIL24;IL17F;IL23R
Inflammatory bowel disease (IBD)HLA-DQA1;STAT1;GATA3;HLA-DMA;Il2;RORA;IL12RB2;RORC;HLA-DMB
Jak-STAT signaling pathwayFHL1;NT5C3;PTPN2A;AOX4;IFNA1;STAT5A;M17;TYK2;IFNA12

IL23R has several biochemical functions, for example, contributes_to interleukin-12 receptor binding, contributes_to interleukin-23 binding, contributes_to interleukin-23 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL23R itself. We selected most functions IL23R had, and list some proteins which have the same functions with IL23R. You can find most of the proteins on our site.

Function Related Protein
contributes_to interleukin-12 receptor bindingIL23R;IL12B;IL12RB1
contributes_to interleukin-23 bindingIL23R;IL12RB1
contributes_to interleukin-23 receptor activityIL12RB1;IL23R
protein bindingALKBH8;BBC3;ZNF329;GLRA1;GDAP2;HSD17B14;TNFAIP1;CDCA5;BCL2L12

IL23R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL23R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL23R.


Research Area

Related articles

Ciccacci, C; Perricone, C; et al. A Multilocus Genetic Study in a Cohort of Italian SLE Patients Confirms the Association with STAT4 Gene and Describes a New Association with HCP5 Gene. PLOS ONE 9:-(2014).
Tillack, C; Ehmann, LM; et al. Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-gamma-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment. GUT 63:567-577(2014).
  • Reviews
  • Q&As

Customer Reviews (3)

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    High specificity in ELISA.


      Effective in autoimmune models.


        Suitable for receptor binding studies.

        Q&As (10)

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        How does IL23R activation affect T-cell differentiation? 12/22/2022

        IL23R activation promotes Th17 cell differentiation.

        Does IL23R have alternative splicing variants? 02/20/2022

        IL23R has multiple alternative splicing variants.

        Does IL23R have any post-translational modifications that affect its stability? 08/23/2021

        IL23R undergoes phosphorylation that affects its stability.

        What is the half-life of IL23R protein in activated T-cells? 08/21/2020

        The half-life of IL23R protein in activated T-cells is approximately 48 hours.

        Are there any microRNAs that regulate IL23R expression? 06/16/2020

        MicroRNAs like miR-20a regulate IL23R expression.

        How does IL23R contribute to cytokine release? 02/15/2019

        IL23R contributes to the release of pro-inflammatory cytokines like IL-17.

        What role does IL23R play in autoimmune diseases? 08/22/2018

        IL23R is implicated in autoimmune diseases like Crohn's.

        How does IL23R expression change during infection? 10/12/2017

        IL23R expression is upregulated during bacterial infection.

        Does IL23R form homodimers or heterodimers? 08/15/2016

        IL23R forms heterodimers with IL-12Rβ1.

        What intracellular pathways are activated by IL23R? 08/06/2016

        IL23R activates the JAK-STAT and NF-κB pathways.

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