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Recombinant Mouse Il31 Protein, His-Tagged

Cat.No. : Il31-01M
Product Overview : Recombinant mouse Il31 Protein, His-tagged was expressed in E. coli cell
  • Specification
  • Gene Information
  • Related Products
Description : Interleukin-31 (IL-31) s an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. It is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.
Source : Escherichia coli
Species : Mouse
Tag : His
Form : Lyophilized powder
AA Sequence : MTCSLSFGAPISKEDLRTTIDLLKQ ESQDLYNNYSIKQASGMSADESIQL PCFSLDREALTNISVIIAHLEKVKV LSENTVDTSWVIRWLTNISCF
NPLNLNISVPGNTDESYDCKVFVLT VLKQFSNCMAELQAKDNTTC with polyhistidine tag at the Cterminus
Endotoxin : <0.1 EU per 1 μg of the protein by the LAL method.
Purity : >98% as determined by SDS-PAGE. Ni-NTA chromatography
Storage Buffer : The protein was lyophilized from a solution containing 1X PBS, pH 7.4.
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Storage : Lyophilized protein should be stored at -20°C. Upon reconstitution, protein aliquots should be stored at -20°C or -80°C.
Notes : Please use within one month after protein reconstitution.
Gene Name : Il31 interleukin 31 [ Mus musculus (house mouse) ]
Official Symbol : Il31
Synonyms : 1700013B14Rik
Gene ID : 76399
mRNA Refseq : NM_029594.2
Protein Refseq : NP_083870.1
UniProt ID : Q6EAL8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the advantages of IL31 compared with other therapeutic methods? 07/19/2022

The IL31 may have specificity for specific diseases, with relatively few side effects being a big advantage.

What is the action mechanism of IL31? 09/26/2020

IL31 activates downstream signaling pathways by binding to receptors and participates in inflammatory response and immune regulation.

In what research areas is this protein used in the laboratory? 09/09/2020

It has a wide range of applications in immune inflammation, dermatology and other research fields.

How is the clinical research progress of IL31? 01/02/2020

Clinical studies of IL31 are ongoing, but there is no clear therapeutic effect and effectiveness assessment at this time.

Are there some challenges in the study of IL31? 10/06/2019

IL31 research still faces many challenges, including side effect evaluation, efficacy verification and other issues, and further efforts are needed.

How to determine the optimal dose of IL31 for treatment? 01/01/2019

Optimal dose may be related to individual differences, disease type and other factors, and the appropriate dose should be determined under the guidance of a doctor when using IL31.

Customer Reviews (3)

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Reviews
04/22/2022

    IL31 product has strict quality control and complies with relevant industry standards.

    09/26/2021

      It performs well in biological activity tests.

      09/13/2020

        This protein has high yield and good economic benefits.

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