Recombinant Mouse Il33 Protein

Cat.No. : Il33-3521M
Product Overview : Purified recombinant protein of Mouse interleukin 33 (Il33), transcript variant 2 without tag was expressed in E. coli.
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Description : In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation.
Source : E. coli
Species : Mouse
Molecular Mass : 17.6 kDa
Protein length : Ser109-Ile266
Endotoxin : Less than 0.1 EU/μg (<0.01 ng/μg) protein as determined by the LAL method
Purity : > 98%, as determined by Coomassie stained SDS-PAGE.
Stability : Unopened vial can be stored between 2 and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Storage : Store at -80 centigrade.
Concentration : Protein formulated and vialed at >50 μg/mL in specified buffer
Storage Buffer : 20 mM HEPES, 150 mM NaCl, pH 7.2, 10 mM TCEP
SDS-PAGE:
Gene Name : Il33 interleukin 33 [ Mus musculus (house mouse) ]
Official Symbol : Il33
Synonyms : Il33; interleukin 33; Il-; Il1f; NF-H; Il-33; Il1f11; NF-HEV; 9230117N10Rik; interleukin-33; nuclear factor from high endothelial venules
Gene ID : 77125
mRNA Refseq : NM_133775
Protein Refseq : NP_598536
UniProt ID : Q8BVZ5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Which immune cells can recombinant IL33 be used to detect? 05/28/2022

It can be used to detect immune cells such as macrophages and dendritic cells.

In what research fields can recombinant IL33 be applied? 09/24/2020

This protein applied in immunology, drug research, life science and other fields.

What is the action mechanism of IL33? 08/09/2020

Regulates the activity of immune cells by binding to receptors to stimulate the production of inflammatory factors such as interferon and TNF-α.

Besides treating asthma and hay fever, what other diseases can be treated with IL33? 07/28/2019

IL33 can also be used to treat a variety of inflammatory diseases, such as inflammatory bowel disease, psoriasis and so on.

How to prepare IL33? 03/25/2019

The preparation of IL33 requires first cloning the IL33 gene into the expression vector, and then the expression vector is expressed and purified in the cell culture medium.

How long does it take to treat asthma with IL33? 01/10/2019

Treating asthma with recombinant IL33 takes several weeks to several months to be effective, depending on the severity of the condition and the individual patient.

Customer Reviews (3)

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Reviews
10/16/2021

    Good solubility and is easy to operate and purify.

    05/03/2021

      Effectively mimics the function of the target protein in vitro.

      03/18/2020

        IL33 has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.

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