Recombinant Mouse Rous Sarcoma Oncogene, SH3 Domain
Cat.No. : | Src-99M |
Product Overview : | Recombinant Mouse Rous Sarcoma Oncogene protein expressed inE.colicontains SH3 domain and has a molecular mass of 33 kDa. |
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Cat. No. : | Src-99M |
Description : | V-src Sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian).A function for Src tyrosine kinases in normal cell growth was first demonstrated with the binding of family member p56lck to the cytoplasmic tail of the CD4 and CD8 co-receptors on T-cells. Src tyrosine kinases also transmit integrin-dependent signals central to cell movement and proliferation. Hallmarks of v-src induced transformation are rounding of the cell and the formation of actin rich podosomes on the basal surface of the cell. These structures are correlated with increased invasiveness, a process thought to be essential for metastasis. |
Source : | Recombinant Mouse Src SH3 domain protein expressed inE.coli. |
Formulation : | Recombinant Mouse Src SH3 domain protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol. |
Application And Suggested Dilutions : | •ELISA •Inhibition Assays •Western Blotting. |
Characterization : | On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 33 kDa. |
Other Ariants Available : | UD DOMAIN, UD/SH3 DOMAIN, UD/SH3/SH2 DOMAIN. |
Storage & Stability : | Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months. |
Tag : | Non |
Gene Name : | Src Rous sarcoma oncogene [ Mus musculus ] |
Synonyms : | Src ; Rous sarcoma oncogene; pp60c-src; AW259666 |
Gene ID : | 20779 |
mRNA Refseq : | NM_001025395 |
Protein Refseq : | NP_001020566 |
UniProt ID : | P05480 |
Chromosome Location : | 2 89.0 cM |
Pathway : | Adherens junction; Endocytosis; ErbB signaling pathway; Focal adhesion; Gap junction; GnRH signaling pathway; Tight junction; VEGF signaling pathway |
Function : | ATP binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein domain specific binding; protein kinase activity; protein tyrosine kinase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
SRC-4276R | Recombinant Rhesus Macaque SRC Protein, His (Fc)-Avi-tagged | +Inquiry |
Src-1368M | Recombinant Mus musculus Src Protein (V85-L535) | +Inquiry |
Src-1367M | Recombinant Mus musculus Src Protein (V85-L535), His-tagged | +Inquiry |
SRC-004H | Active Recombinant Human SRC Protein, GST-tagged | +Inquiry |
SRC-0403H | Recombinant Human SRC Protein (G2-L536), His/Flag tagged | +Inquiry |
◆ Native Protein | ||
SRC-29697TH | Native Human SRC | +Inquiry |
◆ Lysates | ||
SRC-487HCL | Recombinant Human SRC cell lysate | +Inquiry |
SRC-585MCL | Recombinant Mouse SRC cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionChanges in SRC expression or kinase activity can lead to drug resistance in cancer treatment.
SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.
SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.
SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.
SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.
SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.
SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.
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