Recombinant Mouse Rous Sarcoma Oncogene, SH3 Domain

Cat.No. : Src-99M
Product Overview : Recombinant Mouse Rous Sarcoma Oncogene protein expressed inE.colicontains SH3 domain and has a molecular mass of 33 kDa.
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Cat. No. : Src-99M
Description : V-src Sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian).A function for Src tyrosine kinases in normal cell growth was first demonstrated with the binding of family member p56lck to the cytoplasmic tail of the CD4 and CD8 co-receptors on T-cells. Src tyrosine kinases also transmit integrin-dependent signals central to cell movement and proliferation. Hallmarks of v-src induced transformation are rounding of the cell and the formation of actin rich podosomes on the basal surface of the cell. These structures are correlated with increased invasiveness, a process thought to be essential for metastasis.
Source : Recombinant Mouse Src SH3 domain protein expressed inE.coli.
Formulation : Recombinant Mouse Src SH3 domain protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Application And Suggested Dilutions : •ELISA •Inhibition Assays •Western Blotting.
Characterization : On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 33 kDa.
Other Ariants Available : UD DOMAIN, UD/SH3 DOMAIN, UD/SH3/SH2 DOMAIN.
Storage & Stability : Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Gene Name : Src Rous sarcoma oncogene [ Mus musculus ]
Synonyms : Src ; Rous sarcoma oncogene; pp60c-src; AW259666
Gene ID : 20779
mRNA Refseq : NM_001025395
Protein Refseq : NP_001020566
UniProt ID : P05480
Chromosome Location : 2 89.0 cM
Pathway : Adherens junction; Endocytosis; ErbB signaling pathway; Focal adhesion; Gap junction; GnRH signaling pathway; Tight junction; VEGF signaling pathway
Function : ATP binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein domain specific binding; protein kinase activity; protein tyrosine kinase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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01/01/2022

    Top-notch protein purification service, essential for our research.

    08/29/2019

      Reliable mass spectrometry analysis, pivotal for our proteomics work.

      03/02/2019

        Swift and reliable protein sequencing, indispensable for our research success.

        Q&As (7)

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        How do alterations in SRC expression or activity affect the development of drug resistance in tumors? 10/23/2022

        Changes in SRC expression or kinase activity can lead to drug resistance in cancer treatment.

        How does SRC (proto-oncogene tyrosine-protein kinase Src) regulate cell proliferation and survival? 07/08/2021

        SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.

        How does SRC contribute to the regulation of bone remodeling and osteoclast activity? 06/26/2020

        SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.

        What role does SRC play in cancer development and progression, particularly in metastasis? 03/16/2020

        SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.

        How does SRC influence cellular signaling pathways, such as the Ras/MAPK and PI3K/Akt pathways? 12/06/2019

        SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.

        What are the mechanisms by which SRC modulates cellular adhesion and migration? 03/27/2019

        SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.

        What is the impact of SRC inhibition on targeted cancer therapies? 01/02/2018

        SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.

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