Recombinant Rattus Chemokine (C-X-C motif) Ligand 1 (melanoma growth stimulating activity, alpha)

• Cat.No.: Cxcl1-1877R
• Product Overview: Recombinant RatCxcl1 (68 aa).

Specification

• Cat. No.: Cxcl1-1877R
• Description: Chemokine (C-X-Cmotif) ligand 1 (Cxcl1) is a small cytokine belonging to the CXC chemokinefamily that was previously called GRO1 oncogene, GROα, KC,Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulatingactivity, alpha (MSGA-α). In humans, this protein is encoded by the Cxcl1gene.
• Source: E. coli
• Species: Rattus
• Form: Lyophilized from a0.2 µm sterile filtered solution, carrier free.
• Molecular Weight: 7.6kDa
• Purity: > 95% asdetermined by SDS-PAGE analysis.
• Endotoxin Level: < 0.1 ng/µg ofCXCL1
• Biological Activity: Determined by thedose dependent calcium flux in rat neutrophils. The ED50 range is 0.5-2µg/ml.
• Reconstitution: Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration of 0.1-1.0 mg/ml. Further dilutionsshould be made in low endotoxin medium or buffered solution with heatinactivated FCS or tissue culture grade BSA. Please note that the addition ofany carrier protein into this product may produce unwanted endotoxin. Thisdepends upon the particular application employed.
• Storage: Store lyophilizedprotein at 2-4°C and reconstituted protein in working aliquots at -20°C to-80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: Cxcl1
• Tag: Non

Gene Information

• Gene Name: Cxcl1 chemokine (C-X-C motif)ligand 1 (melanoma growth stimulating activity, alpha) [ Rattus norvegicus]
• Synonyms: Cxcl1; chemokine(C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); Gro1;CINC-1; growth-regulated alpha protein; gro; C-X-C motif chemokine 1;cytokine-induced neutrophil chemoattractant 1; platelet-derived growthfactor-inducible protein KC
• Gene ID: 81503
• mRNA Refseq: NM_030845
• Protein Refseq: NP_110472
• UniProt ID: P14095
• Chromosome Location: 14p22
• Pathway: Chemokine receptorsbind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-likereceptors); Cytokines and Inflammatory Response (BioCarta); G alpha (i)signalling events; GPCR downstream signaling; GPCR ligand binding;Legionellosis; NOD-like receptor signaling pathway; Peptide ligand-bindingreceptors; Salmonella infection; Signal Transduction; Signaling by GPCR
• Function: chemokine activity;growth factor activity

Citation

β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration.

Journal: Nature    PubMed ID: 30787438    Data: 2019/8/12

Authors: Dmitri Lodygin, Moritz Hermann, Alexander Flügel

Article Snippet:Antigens.. MBP was extracted from guinea pig brain as described40, OVA was purchased from Sigma, recombinant rat β-synuclein was purchased from Creative BioMart or purified in-house from bacterial E. coli lysates expressing recombinant protein with C-terminal 6×His tag using a Ni-agarose column.. All peptides were synthetized by the peptide facility of the Charité (Berlin).All peptides were synthetized by the peptide facility of the Charité (Berlin).

Reviews

06/15/2020

Efficient delivery, great service.

01/01/2019

Product as described, perfect.

10/13/2018

Reliable for protein work.

Q&As

Are there any therapeutic strategies targeting CXCL1?

Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.

How does CXCL1 contribute to inflammation?

It mediates inflammation by promoting leukocyte migration and activation.

What role does CXCL1 play in tumor progression?

In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.

What is the relationship between CXCL1 and angiogenesis?

CXCL1 contributes to angiogenesis, supporting new blood vessel formation.

What is the primary function of CXCL1 in the immune system?

CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.

In which pathological conditions is CXCL1 found to be elevated?

CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.

How is the expression of CXCL1 regulated in cells?

CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.