Recombinant Rattus Chemokine (C-X-C motif) Ligand 1 (melanoma growth stimulating activity, alpha)
|Product Overview :||Recombinant RatCxcl1 (68 aa).|
- Gene Information
- Related Products
|Cat. No. :||Cxcl1-1877R|
|Description :||Chemokine (C-X-Cmotif) ligand 1 (Cxcl1) is a small cytokine belonging to the CXC chemokinefamily that was previously called GRO1 oncogene, GROα, KC,Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulatingactivity, alpha (MSGA-α). In humans, this protein is encoded by the Cxcl1gene.|
|Source :||E. coli|
|Form :||Lyophilized from a0.2 µm sterile filtered solution, carrier free.|
|Molecular Weight :||7.6kDa|
|Purity :||> 95% asdetermined by SDS-PAGE analysis.|
|Endotoxin Level :||< 0.1 ng/µg ofCXCL1|
|Biological Activity :||Determined by thedose dependent calcium flux in rat neutrophils. The ED50 range is 0.5-2µg/ml.|
|Reconstitution :||Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration of 0.1-1.0 mg/ml. Further dilutionsshould be made in low endotoxin medium or buffered solution with heatinactivated FCS or tissue culture grade BSA. Please note that the addition ofany carrier protein into this product may produce unwanted endotoxin. Thisdepends upon the particular application employed.|
|Storage :||Store lyophilizedprotein at 2-4°C and reconstituted protein in working aliquots at -20°C to-80°C. Avoid repeated freeze-thaw cycles.|
|Gene Name :||Cxcl1 chemokine (C-X-C motif)ligand 1 (melanoma growth stimulating activity, alpha) [ Rattus norvegicus]|
|Synonyms :||Cxcl1; chemokine(C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); Gro1;CINC-1; growth-regulated alpha protein; gro; C-X-C motif chemokine 1;cytokine-induced neutrophil chemoattractant 1; platelet-derived growthfactor-inducible protein KC|
|Gene ID :||81503|
|mRNA Refseq :||NM_030845|
|Protein Refseq :||NP_110472|
|UniProt ID :||P14095|
|Chromosome Location :||14p22|
|Pathway :||Chemokine receptorsbind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-likereceptors); Cytokines and Inflammatory Response (BioCarta); G alpha (i)signalling events; GPCR downstream signaling; GPCR ligand binding;Legionellosis; NOD-like receptor signaling pathway; Peptide ligand-bindingreceptors; Salmonella infection; Signal Transduction; Signaling by GPCR|
|Function :||chemokine activity;growth factor activity|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (7)Ask a question
Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.
It mediates inflammation by promoting leukocyte migration and activation.
In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.
CXCL1 contributes to angiogenesis, supporting new blood vessel formation.
CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.
CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.
CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.
Customer Reviews (3)Write a review
Efficient delivery, great service. -
Product as described, perfect. -
Reliable for protein work. -
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