Native Human CXCL1

Cat.No. : CXCL1-27707TH
Product Overview : Human GRO alpha.
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Description : Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CXC chemokines are further subdivided into ELR and non-ELR types based on the presence or absence of a glu-leu-arg sequence adjacent and N terminal to the CXC motif. ELR types are chemotactic for neutrophils, while non-ELR types are chemotactic for lymphocytes.
Source : E. coli
Form : Lyophilised
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : Recombinant Human GRO alpha (MGSA) is a 7.8 kDa protein containing 73 amino acid residues:ASVATELRCQCLQTLQGIHPKNIQSVNVKSPGPHCAQTEVIATLKN GRKACLNPASPIVKKIIEKLLNSDKSN
Sequence Similarities : Belongs to the intercrine alpha (chemokine CxC) family.
Gene Name : CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [ Homo sapiens ]
Official Symbol : CXCL1
Synonyms : CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); fibroblast secretory protein , FSP, GRO1, GRO1 oncogene (melanoma growth stimulating activity, alpha) , MGSA; growth-regulated alpha protein; GROa; MGSA a; NAP 3; SCYB
Gene ID : 2919
mRNA Refseq : NM_001511
Protein Refseq : NP_001502
MIM : 155730
Uniprot ID : P09341
Chromosome Location : 4q13.3
Pathway : Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem;
Function : chemokine activity; enzyme activator activity; growth factor activity; receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
06/15/2020

    Efficient delivery, great service.

    01/01/2019

      Product as described, perfect.

      10/13/2018

        Reliable for protein work.

        Q&As (7)

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        Are there any therapeutic strategies targeting CXCL1? 11/17/2022

        Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.

        How does CXCL1 contribute to inflammation? 05/03/2022

        It mediates inflammation by promoting leukocyte migration and activation.

        What role does CXCL1 play in tumor progression? 09/30/2021

        In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.

        What is the relationship between CXCL1 and angiogenesis? 04/21/2021

        CXCL1 contributes to angiogenesis, supporting new blood vessel formation.

        What is the primary function of CXCL1 in the immune system? 11/15/2019

        CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.

        In which pathological conditions is CXCL1 found to be elevated? 08/05/2018

        CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.

        How is the expression of CXCL1 regulated in cells? 02/06/2018

        CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.

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