Recombinant Human Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha), MBP-tagged

Cat.No. : CXCL1-162H
Product Overview : Recombinant CXCL1 protein was expressed in E.coli and purified by using conventional chromatography techniques, 52591,6 Da (481aa).
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Cat. No. : CXCL1-162H
Description : CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. An initial study in mice showed evidence that CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function.
Sequences of amino acids : MARAALSAAP SNPRLLRVAL LLLLLVAAGR RAAGASVATE LRCQCLQTLQ GIHPKNIQSV NVKSPGPHCA QTEVIATLKN GRKACLNPAS PIVKKIIEKM LNSDKSN
Formulation : Supplied in phosphate buffered saline (PBS) and 30% glycerol, pH 7.4 and contains not preservatives.
Applications : ELISA; WB; Antibody Production; Protein array
Testing protocols : 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-MBP (WB) and peptide fingerprinting by MALDI-TOF mass spectrometry
Gene Name : CXCL1 chemokine (C-X-C motif) ligand1 (melanoma growth stimulating activity, alpha) [Homo sapiens]
Synonyms : Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); SCYB1; GROa MGSA-a; NAP-3; MGSA; GRO1; FSP; GRO1 oncogene (melanoma growth stimulating activity, alpha); GRO1 oncogene (melanoma growth-stimulating activity); fibroblast secretory protein; CXCL1; Growth-regulated alpha protein; C-X-C motif chemokine 1; GRO-alpha (1-73); Melanoma growth stimulatory activity; Neutrophil-activating protein 3; GRO; GROA; SCYB1; MGSA alpha; melanoma growth stimulatory activity alpha
Gene ID : 2919
mRNA Refseq : NM_001511
Protein Refseq : NP_001502
MIM : 155730
UniProt ID : P09341
Chromosome Location : 4q21
Pathway : Amoebiasis; Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; NOD-like receptor signaling pathway
Function : Chemokine activity; enzyme activator activity; growth factor activity; receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there any therapeutic strategies targeting CXCL1? 11/17/2022

Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.

How does CXCL1 contribute to inflammation? 05/03/2022

It mediates inflammation by promoting leukocyte migration and activation.

What role does CXCL1 play in tumor progression? 09/30/2021

In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.

What is the relationship between CXCL1 and angiogenesis? 04/21/2021

CXCL1 contributes to angiogenesis, supporting new blood vessel formation.

What is the primary function of CXCL1 in the immune system? 11/15/2019

CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.

In which pathological conditions is CXCL1 found to be elevated? 08/05/2018

CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.

How is the expression of CXCL1 regulated in cells? 02/06/2018

CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.

Customer Reviews (3)

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Reviews
06/15/2020

    Efficient delivery, great service.

    01/01/2019

      Product as described, perfect.

      10/13/2018

        Reliable for protein work.

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