Recombinant Human Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha), MBP-tagged

• Cat.No.: CXCL1-162H
• Product Overview: Recombinant CXCL1 protein was expressed in E.coli and purified by using conventional chromatography techniques, 52591,6 Da (481aa).

Specification

• Cat. No.: CXCL1-162H
• Description: CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. An initial study in mice showed evidence that CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function.
• Sequences of amino acids: MARAALSAAP SNPRLLRVAL LLLLLVAAGR RAAGASVATE LRCQCLQTLQ GIHPKNIQSV NVKSPGPHCA QTEVIATLKN GRKACLNPAS PIVKKIIEKM LNSDKSN
• Formulation: Supplied in phosphate buffered saline (PBS) and 30% glycerol, pH 7.4 and contains not preservatives.
• Applications: ELISA; WB; Antibody Production; Protein array
• Testing protocols: 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-MBP (WB) and peptide fingerprinting by MALDI-TOF mass spectrometry

Gene Information

• Gene Name: CXCL1 chemokine (C-X-C motif) ligand1 (melanoma growth stimulating activity, alpha) [Homo sapiens]
• Synonyms: Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); SCYB1; GROa MGSA-a; NAP-3; MGSA; GRO1; FSP; GRO1 oncogene (melanoma growth stimulating activity, alpha); GRO1 oncogene (melanoma growth-stimulating activity); fibroblast secretory protein; CXCL1; Growth-regulated alpha protein; C-X-C motif chemokine 1; GRO-alpha (1-73); Melanoma growth stimulatory activity; Neutrophil-activating protein 3; GRO; GROA; SCYB1; MGSA alpha; melanoma growth stimulatory activity alpha
• Gene ID: 2919
• mRNA Refseq: NM_001511
• Protein Refseq: NP_001502
• MIM: 155730
• UniProt ID: P09341
• Chromosome Location: 4q21
• Pathway: Amoebiasis; Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; NOD-like receptor signaling pathway
• Function: Chemokine activity; enzyme activator activity; growth factor activity; receptor binding

Reviews

06/15/2020

Efficient delivery, great service.

01/01/2019

Product as described, perfect.

10/13/2018

Reliable for protein work.

Q&As

Are there any therapeutic strategies targeting CXCL1?

Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.

How does CXCL1 contribute to inflammation?

It mediates inflammation by promoting leukocyte migration and activation.

What role does CXCL1 play in tumor progression?

In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.

What is the relationship between CXCL1 and angiogenesis?

CXCL1 contributes to angiogenesis, supporting new blood vessel formation.

What is the primary function of CXCL1 in the immune system?

CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.

In which pathological conditions is CXCL1 found to be elevated?

CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.

How is the expression of CXCL1 regulated in cells?

CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.