agr2
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  • Official Full Name
  • anterior gradient 2 homolog (Xenopus laevis)
  • Background
  • AGR2 (Anterior Gradient 2), also known as AG2 (hAG2, HAG2 in human), or GOB4, and AGR3 (Anterior Gradient 3), also known as AG3 (hAG3, HAG3 in human), or BCMP11, are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours; AGR2 was reported also as a marker of other carcinomas. Xenopus homolog of these proteins is associated with anteroposterior fate determination during early development.
  • Synonyms
  • AGR2; anterior gradient 2 homolog (Xenopus laevis); anterior gradient protein 2 homolog; AG2; HAG 2; PDIA17; protein disulfide isomerase family A; member 17; XAG 2; AG-2; HPC8; anterior gradient homolog 2; secreted cement gland homolog; secreted cement gl
Cat.#:AGR2-520HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AGR2 Protein, MYC/DDK-tagged
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Cat.#:Agr2-502RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Agr2 Protein, His-tagged
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Cat.#:AGR2-26141THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AGR2, His-tagged
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Cat.#:AGR2-230HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human AGR2 Protein, His-tagged
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Cat.#:AGR2-439HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AGR2 Protein, GST-tagged
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Cat.#:AGR2-440HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AGR2 Protein, GST-tagged
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Cat.#:AGR2-441HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AGR2 Protein, GST-tagged
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Cat.#:AGR2-63HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AGR2, His-tagged
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Cat.#:AGR2-9481HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AGR2, GST-tagged
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Cat.#:Agr2-126MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Agr2 protein, His-tagged
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Cat.#:AGR2-1425MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AGR2 Protein
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Cat.#:Agr2-3504MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Agr2, His-tagged
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Cat.#:AGR2-273RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AGR2 Protein, His-tagged
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Cat.#:AGR2-2046ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AGR2
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Cat.#:AGR2-8972HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human AGR2 293 Cell Lysate
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Protein Function

AGR2 has several biochemical functions, for example, dystroglycan binding, epidermal growth factor receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGR2 itself. We selected most functions AGR2 had, and list some proteins which have the same functions with AGR2. You can find most of the proteins on our site.
Function
Related Protein
Function dystroglycan binding
Related Protein AGRN; DMD; VCL; GYLTL1B; AGR2; MAP2; AGR3; DAG1; CLASP1
Function epidermal growth factor receptor binding
Related Protein FAM83B; ERBB4; SHC1; CBLC; EFEMP1; ATXN2; YES1; TGFA; VAV3; HBEGF
Function protein binding
Related Protein CLCF1; UTP3; ZNF263; PPP1R9B; RAB11B; DCDC2; VPS11; CBR2; MACROD1; TAPBP
Function protein homodimerization activity
Related Protein HSD17B4; BMP4; SDCBP; MVD; BCL2; NBL1; HMGCS1; FZD1; UGT1A6B; OXA1L

Interacting Protein

AGR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGR2.
POM121; FABP2; KRT31; CATSPER1; NUP62CL; UBQLN1; UBQLN1

AGR2 Related Articles

Mizuuchi, Y; Aishima, S; et al. Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition. LABORATORY INVESTIGATION 95:193-206(2015).
Pentheroudakis, G; Kotoula, V; et al. A study of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: a translational research study of the Hellenic Cooperative Oncology Group (HeCOG). BMC CANCER 14:-(2014).