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Recombinant Human AGR2 Protein, GST-tagged

Cat.No. : AGR2-439H
Product Overview : Human AGR2 full-length ORF ( AAH15503.1, 1 a.a. - 175 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 44.99 kDa
AA Sequence : MEKIPVSAFLLLVALSYTLARDTTV KPGAKKDTKDSRPKLPQTLSRGWGD QLIWTQTYEEALYKSKTSNKPLMII HHLDECPHSQALKKVFAENKEIQKL AEQFVLLNLVYETTDKHLSPDGQYV PRIMFVDPSLTVRADITGRYSNRLY AYEPADTALLLDNMKKALKLLKTEL
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : AGR2 anterior gradient 2 homolog (Xenopus laevis) [ Homo sapiens ]
Official Symbol : AGR2
Synonyms : AGR2; anterior gradient 2 homolog (Xenopus laevis); anterior gradient protein 2 homolog; AG2; HAG 2; PDIA17; protein disulfide isomerase family A; member 17; XAG 2; AG-2; HPC8; anterior gradient homolog 2; secreted cement gland homolog; secreted cement gland protein XAG-2 homolog; protein disulfide isomerase family A, member 17; GOB-4; HAG-2; XAG-2;
Gene ID : 10551
mRNA Refseq : NM_006408
Protein Refseq : NP_006399
MIM : 606358
UniProt ID : O95994

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Does AGR2 expression correlate with patient prognosis? 03/19/2022

High levels of AGR2 expression have been associated with poorer prognosis in several types of cancer, indicating its potential as a prognostic biomarker.

How does AGR2 contribute to cancer metastasis? 02/10/2022

AGR2 promotes cancer cell migration and invasion by modulating signaling pathways involved in epithelial-to-mesenchymal transition (EMT) and extracellular matrix remodeling.

What is the function of AGR2? 06/12/2021

AGR2 has been implicated in protein folding, quality control, and secretion of other proteins. It is also involved in cancer progression and metastasis.

What is the role of AGR2 in endoplasmic reticulum (ER) stress? 11/10/2020

AGR2 is upregulated in response to ER stress and helps restore ER homeostasis by promoting protein folding and reducing ER stress-induced apoptosis.

How is AGR2 involved in protein folding and quality control? 03/19/2020

AGR2 acts as a chaperone protein, facilitating the correct folding of secretory proteins and assisting in their quality control before secretion.

Are there any inhibitors or modulators of AGR2? 03/12/2020

Several small molecules and antibodies targeting AGR2 have been developed as potential therapeutic agents, but further research is needed to validate their efficacy.

Are there any AGR2-related genetic polymorphisms associated with disease? 01/29/2020

Some genetic variants in the AGR2 gene have been associated with an increased risk of certain cancers, including prostate and breast cancer.

What role does AGR2 play in cancer? 07/20/2019

AGR2 is overexpressed in various cancers, including breast, prostate, lung, and ovarian cancers, and has been associated with tumor growth, invasion, and drug resistance.

What are the downstream signaling pathways regulated by AGR2? 10/22/2018

AGR2 can activate signaling pathways such as the PI3K/AKT pathway, Wnt/β-catenin pathway, and MAPK/ERK pathway, which are involved in cell survival, proliferation, and migration.

Can AGR2 be used as a diagnostic marker for cancer? 05/21/2018

Yes, elevated levels of AGR2 have been detected in the blood and tissue samples of cancer patients, making it a potential biomarker for cancer diagnosis.

Customer Reviews (5)

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Reviews
05/13/2022

    Very impressed.

    02/26/2020

      Excellent value for its price

      02/15/2020

        The customer support was also excellent, providing prompt assistance when needed.

        01/28/2018

          The customer service was responsive and assisted me with technical questions.

          01/01/1900

            The purity and activity of the protein were exceptional, and it worked perfectly in my experiments.

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