Recombinant Human AGR2 Protein, GST-tagged
Cat.No. : | AGR2-439H |
Product Overview : | Human AGR2 full-length ORF ( AAH15503.1, 1 a.a. - 175 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 44.99 kDa |
AA Sequence : | MEKIPVSAFLLLVALSYTLARDTTV KPGAKKDTKDSRPKLPQTLSRGWGD QLIWTQTYEEALYKSKTSNKPLMII HHLDECPHSQALKKVFAENKEIQKL AEQFVLLNLVYETTDKHLSPDGQYV PRIMFVDPSLTVRADITGRYSNRLY AYEPADTALLLDNMKKALKLLKTEL |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AGR2 anterior gradient 2 homolog (Xenopus laevis) [ Homo sapiens ] |
Official Symbol : | AGR2 |
Synonyms : | AGR2; anterior gradient 2 homolog (Xenopus laevis); anterior gradient protein 2 homolog; AG2; HAG 2; PDIA17; protein disulfide isomerase family A; member 17; XAG 2; AG-2; HPC8; anterior gradient homolog 2; secreted cement gland homolog; secreted cement gland protein XAG-2 homolog; protein disulfide isomerase family A, member 17; GOB-4; HAG-2; XAG-2; |
Gene ID : | 10551 |
mRNA Refseq : | NM_006408 |
Protein Refseq : | NP_006399 |
MIM : | 606358 |
UniProt ID : | O95994 |
Products Types
◆ Recombinant Protein | ||
AGR2-292H | Recombinant Human AGR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Agr2-1560M | Recombinant Mouse Agr2 Protein, Myc/DDK-tagged | +Inquiry |
Agr2-502R | Recombinant Rat Agr2 Protein, His-tagged | +Inquiry |
AGR2-520H | Recombinant Human AGR2 Protein, MYC/DDK-tagged | +Inquiry |
AGR2-101R | Recombinant Rhesus Macaque AGR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
AGR2-8972HCL | Recombinant Human AGR2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionHigh levels of AGR2 expression have been associated with poorer prognosis in several types of cancer, indicating its potential as a prognostic biomarker.
AGR2 promotes cancer cell migration and invasion by modulating signaling pathways involved in epithelial-to-mesenchymal transition (EMT) and extracellular matrix remodeling.
AGR2 has been implicated in protein folding, quality control, and secretion of other proteins. It is also involved in cancer progression and metastasis.
AGR2 is upregulated in response to ER stress and helps restore ER homeostasis by promoting protein folding and reducing ER stress-induced apoptosis.
AGR2 acts as a chaperone protein, facilitating the correct folding of secretory proteins and assisting in their quality control before secretion.
Several small molecules and antibodies targeting AGR2 have been developed as potential therapeutic agents, but further research is needed to validate their efficacy.
Some genetic variants in the AGR2 gene have been associated with an increased risk of certain cancers, including prostate and breast cancer.
AGR2 is overexpressed in various cancers, including breast, prostate, lung, and ovarian cancers, and has been associated with tumor growth, invasion, and drug resistance.
AGR2 can activate signaling pathways such as the PI3K/AKT pathway, Wnt/β-catenin pathway, and MAPK/ERK pathway, which are involved in cell survival, proliferation, and migration.
Yes, elevated levels of AGR2 have been detected in the blood and tissue samples of cancer patients, making it a potential biomarker for cancer diagnosis.
Customer Reviews (5)
Write a reviewVery impressed.
Excellent value for its price
The customer support was also excellent, providing prompt assistance when needed.
The customer service was responsive and assisted me with technical questions.
The purity and activity of the protein were exceptional, and it worked perfectly in my experiments.
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