Recombinant Full Length Human AGR2 Protein, C-Flag-tagged

• Cat.No.: AGR2-936HFL
• Product Overview: Recombinant Full Length Human AGR2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 19.8 kDa
• AA Sequence: MEKIPVSAFLLLVALSYTLARDTTV KPGAKKDTKDSRPKLPQTLSRGWGD QLIWTQTYEEALYKSKTSNK PLMIIHHLDECPHSQALKKVFAENK EIQKLAEQFVLLNLVYETTDKHLSP DGQYVPRIMFVDPSLTVRAD
  ITGRYSNRLYAYEPADTALLLDNMK KALKLLKTELTRTRPLEQKLISEED LAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Secreted Protein

Gene Information

• Gene Name: AGR2 anterior gradient 2, protein disulphide isomerase family member [ Homo sapiens (human) ]
• Official Symbol: AGR2
• Synonyms: AG2; AG-2; HPC8; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116
• Gene ID: 10551
• mRNA Refseq: NM_006408.4
• Protein Refseq: NP_006399.1
• MIM: 606358
• UniProt ID: O95994