Recombinant Human AGR2 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: AGR2-3191H
• Product Overview: AGR2 MS Standard C13 and N15-labeled recombinant protein (NP_006399) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 19.8 kDa
• AA Sequence: MEKIPVSAFLLLVALSYTLARDTTV KPGAKKDTKDSRPKLPQTLSRGWGD QLIWTQTYEEALYKSKTSNKPLMII HHLDECPHSQALKKVFAENKEIQKL AEQFVLLNLVYETTDKHLSPDGQYV PRIMFVDPSLTVRADITGRYSNRLY AYEPADTALLLDNMKKALKLLKTEL TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: AGR2 anterior gradient 2, protein disulphide isomerase family member [ Homo sapiens (human) ]
• Official Symbol: AGR2
• Synonyms: AGR2; anterior gradient 2 homolog (Xenopus laevis); anterior gradient protein 2 homolog; AG2; HAG 2; PDIA17; protein disulfide isomerase family A; member 17; XAG 2; AG-2; HPC8; anterior gradient homolog 2; secreted cement gland homolog; secreted cement gland protein XAG-2 homolog; protein disulfide isomerase family A, member 17; GOB-4; HAG-2; XAG-2
• Gene ID: 10551
• mRNA Refseq: NM_006408
• Protein Refseq: NP_006399
• MIM: 606358
• UniProt ID: O95994