Recombinant Human AGR2 Protein, His-tagged

• Cat.No.: AGR2-230H
• Product Overview: Recombinant Human AGR2(Arg20-Leu175) fused with His tag at N-terminal was expressed in HEK296 cells.

Specification

• Description: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.
• Source: HEK293 cells
• Tag: His
• Form: Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.2. Stable for at least 6 months from date of receipt under proper storage and handling conditions.
• Molecular Mass: 18.9 kDa
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: Resuspend the protein to the desired concentration in proper buffer.

Gene Information

• Gene Name: AGR2 anterior gradient 2 homolog (Xenopus laevis) [ Homo sapiens ]
• Official Symbol: AGR2
• Synonyms: AGR2; anterior gradient 2 homolog (Xenopus laevis); anterior gradient protein 2 homolog; AG2; HAG 2; PDIA17; protein disulfide isomerase family A; member 17; XAG 2; AG-2; HPC8; anterior gradient homolog 2; secreted cement gland homolog; secreted cement gland protein XAG-2 homolog; protein disulfide isomerase family A, member 17; GOB-4; HAG-2; XAG-2
• Gene ID: 10551
• mRNA Refseq: NM_006408
• Protein Refseq: NP_006399
• MIM: 606358
• UniProt ID: O95994