acvrl1
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  • Official Full Name
  • activin A receptor type II-like 1
  • Background
  • This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ACVRL1; activin A receptor type II-like 1; HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1; serine/threonine-protein kinase receptor R3; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 1;
Cat.#:ACVRL1-1154HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVRL1 Protein, MYC/DDK-tagged
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Cat.#:ACVRL1-238HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Activin A Receptor Type II-like 1, GST-tagged, Active
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Cat.#:ACVRL1-483HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Activin A Receptor Type II-Like 1
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Cat.#:Acvrl1-498MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Activin A Receptor, Type II-like 1, Fc-tagged
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Cat.#:ACVRL1-260HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACVRL1 Protein, GST-tagged
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Cat.#:ACVRL1-360HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human ACVRL1 Protein, His-tagged
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Cat.#:ACVRL1-534HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human ACVRL1, Fc-tagged, Biotinylated
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Cat.#:ACVRL1-644HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVRL1, His tagged
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Cat.#:ACVRL1-768HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVRL1, Fc tagged
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Cat.#:ACVRL1-9359HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACVRL1, GST-tagged
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Cat.#:Acvrl1-2333MTag:Fc|His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Acvrl1, Fc-His tagged
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Cat.#:Acvrl1-245RTag:Fc|His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Acvrl1, Fc-His tagged
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Cat.#:ACVRL1-496RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ACVRL1 Protein
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Cat.#:ACVRL1-1186CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACVRL1 Protein, His-tagged
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Cat.#:ACVRL1-8813CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACVRL1, Fc tagged
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Cat.#:ACVRL1-318CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine ACVRL1, Fc tagged
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Cat.#:ACVRL1-9455ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ACVRL1
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Cat.#:ACVRL1-2629HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVRL1 cell lysate
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Cat.#:ACVRL1-3093MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ACVRL1 cell lysate
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Cat.#:ACVRL1-3001RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat ACVRL1 cell lysate
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Cat.#:ACVRL1-1191CCLTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACVRL1 cell lysate
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Cat.#:ACVRL1-994CCLTag:N/A
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine ACVRL1 cell lysate
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Cat.#:ACVRL1-P010HTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human ACVRL1, Fc-tagged therapeutic protein
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Involved Pathway

Acvrl1 involved in several pathways and played different roles in them. We selected most pathways Acvrl1 participated on our site, such as ALK1 pathway, ALK1 signaling events, Id Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Acvrl1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ALK1 pathway
ACVRL1; FKBP1A
ALK1 signaling events
FKBP1A; CSNK2B; GDF2; ACVRL1
Id Signaling Pathway
IFI16; MYF6; MYOG; PAX2; MYOD1; TCF3B; KDR; MSC; ELK3; ACVRL1
TGF-beta Receptor Signaling Pathway
VDRB; CTCF; TGFBR3; HOXD9A; STRAP; ENG; SKIA; STK11IP; SNIP1; COPS5

Protein Function

Acvrl1 has several biochemical functions, for example, ATP binding, SMAD binding, activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Acvrl1 itself. We selected most functions Acvrl1 had, and list some proteins which have the same functions with Acvrl1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DDX39; PEBP1; STK36; KIF2C; TRIT1; ATP4A; MKNK2B; NAIP7; CDK2; CSNK2A2A
Function SMAD binding
Related Protein PURB; COL1A2; BMPR1A; EID2; TCF12; CREBBP; SKOR1; FOXH1; ACVRL1; SNW1
Function activin binding
Related Protein ACVR1; FKBP1A; FSTL3; SMURF1; SMAD7; TGFBR3; ACVR2B; FST; ENG; ACVRL1
Function activin receptor activity, type I
Related Protein ACVR1B; ACVR1C; ACVRL1
Function contributes_to activin receptor activity, type I
Related Protein ACVRL1; ACVR1
Function metal ion binding
Related Protein GGPS1; AKAP8L; ZBTB7B; Adcy4; PGCP; ZNF134; NCALDB; LMO7A; FGG; SAR1B
Function protein binding
Related Protein PTRH2; TFB1M; FAM21C; HIC1; RGP1; RNF220; TPP2; CCT3; VASN; E4F1
Function protein kinase binding
Related Protein LATS1; MAP2K3; DUSP3; RNF138; RCC2; FAF1; CNPPD1; CDC25C; HDAC7; SLC12A5
Function protein serine/threonine kinase activity
Related Protein DAPK3; MAPK1; TGFBR1; GRK1B; CSNK1G2; PLK2; ACVR1L; MLKL; CLK3; MAP3K8
Function receptor signaling protein serine/threonine kinase activity
Related Protein BMPR1B; SBK3; STK39; ACVRL1; ACVR2AA; BMPR1AB; TGFBR1A; ALPK2; STK26; ACVR1
Function transforming growth factor beta binding
Related Protein THBS1; ACVRL1; ACVR1; CD109; ENG; TGFBR2; TGFB3; LTBP4; VASN; HYAL2
Function contributes_to transforming growth factor beta receptor activity, type I
Related Protein ACVRL1
Function transforming growth factor beta-activated receptor activity
Related Protein LTBP1; BMPR2B; TGFBR3; BMPR2A; ACVRL1; TGFBR2; ENG; TGFBR1
Function transmembrane receptor protein serine/threonine kinase activity
Related Protein BMPR1B; BMPR1BA; ACVR1; TGFBR2; BMPR2B; BMPR1AA; BMPR1AB; ACVR1BA; ACVR2A; BMPR1BB

Interacting Protein

Acvrl1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Acvrl1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Acvrl1.
ITGA5