Recombinant Human ACVRL1 Protein, GST-tagged

• Cat.No.: ACVRL1-260H
• Product Overview: Human ACVRL1 full-length ORF ( AAH42637, 22 a.a. - 503 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 78.76 kDa
• AA Sequence: DPVKPSRGPLVTCTCESPHCKGPTC RGAWCTVVLVREEGRHPQEHRGCGN LHRELCRGRPTEFVNHYCCDSHLCN HNVSLVLEATQPPSEQPGTDGQLAL ILGPVLALLALVALGVLGLWRVRRR QEKQRGLHSELGESSLILKASEQGD SMLGDLLDSDCTTGSGSGLPFLVQR TVARQVALVECVGKGRYGEVWRGLW HGESVAVKIFSSRDEQSWFRETEIY NTVLLRHDNILGFIASDMTSRNSST QLWLITHYHEHGSLYDFLQRQTLEP HLALRLAVSAACGLAHLHVEIFGTQ GKPAIAHRDFKSRNVLVKSNLQCCI ADLGLAVMHSQGSDYLDIGNNPRVG TKRYMAPEVLDEQIRTDCFESYKWT DIWAFGLVLWEIARRTIVNGIVEDY RPPFYDVVPNDPSFEDMKKVVCVDQ QTPTIPNRLAADPVLSGLAQMMREC WYPNPSARLTALRIKKTLQKISNSP EKPKVIQ
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ACVRL1 activin A receptor type II-like 1 [ Homo sapiens ]
• Official Symbol: ACVRL1
• Synonyms: ACVRL1; activin A receptor type II-like 1; ACVRLK1, ORW2; serine/threonine-protein kinase receptor R3; ALK1; HHT; HHT2; activin receptor-like kinase 1; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 1; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1
• Gene ID: 94
• mRNA Refseq: NM_000020
• Protein Refseq: NP_000011
• MIM: 601284
• UniProt ID: P37023