Recombinant Full Length Human ACVRL1 Protein, C-Flag-tagged

• Cat.No.: ACVRL1-1507HFL
• Product Overview: Recombinant Full Length Human ACVRL1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 55.9 kDa
• AA Sequence: MTLGSPRKGLLMLLMALVTQGDPVK PSRGPLVTCTCESPHCKGPTCRGAW CTVVLVREEGRHPQEHRGCG NLHRELCRGRPTEFVNHYCCDSHLC NHNVSLVLEATQPPSEQPGTDGQLA LILGPVLALLALVALGVLGL WHVRRRQEKQRGLHSELGESSLILK ASEQGDSMLGDLLDSDCTTGSGSGL PFLVQRTVARQVALVECVGK GRYGEVWRGLWHGESVAVKIFSSRD EQSWFRETEIYNTVLLRHDNILGFI ASDMTSRNSSTQLWLITHYH EHGSLYDFLQRQTLEPHLALRLAVS AACGLAHLHVEIFGTQGKPAIAHRD FKSRNVLVKSNLQCCIADLG LAVMHSQGSDYLDIGNNPRVGTKRY MAPEVLDEQIRTDCFESYKWTDIWA FGLVLWEIARRTIVNGIVED YRPPFYDVVPNDPSFEDMKKVVCVD QQTPTIPNRLAADPVLSGLAQMMRE CWYPNPSARLTALRIKKTLQ
  KISNSPEKPKVIQTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

Gene Information

• Gene Name: ACVRL1 activin A receptor like type 1 [ Homo sapiens (human) ]
• Official Symbol: ACVRL1
• Synonyms: HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1
• Gene ID: 94
• mRNA Refseq: NM_001077401.2
• Protein Refseq: NP_001070869.1
• MIM: 601284
• UniProt ID: P37023