BAK1
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Official Full Name
BCL2-antagonist/killer 1 -
Overview
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008] -
Synonyms
BAK1;BCL2-antagonist/killer 1;BAK;CDN1;BCL2L7;BAK-LIKE;bcl-2 homologous antagonist/killer;bcl2-L-7;BCL2-like 7 protein;bcl-2-like protein 7;apoptosis regulator BAK;pro-apoptotic protein BAK
Recombinant Proteins
- Chicken
- Human
- Rhesus macaque
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
BAK1 involved in several pathways and played different roles in them. We selected most pathways BAK1 participated on our site, such as Protein processing in endoplasmic reticulum,Viral carcinogenesis,MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | SIL1,DNAJB12,DNAJB12A,HSPA1B,FBXO6,DNAJC3A,NFE2L2,HSP90AB1,TXNDC5,HSPA1L |
| MicroRNAs in cancer | CYP24A1,ATM,MMP9,GRB2,MAPK7,WNT3A,CCND2,PIM1,PDGFB,ABL1 |
| Viral carcinogenesis | KAT2A,CDC42,STAT3,STAT5A,SP100,MRPS18B,RB1,PIK3CB,GTF2A1,CCNA2 |
Protein Function
BAK1 has several biochemical functions, for example, BH domain binding,chaperone binding,heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAK1 itself. We selected most functions BAK1 had, and list some proteins which have the same functions with BAK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | PHC2B,HIST1H2B5,H3F3C,IRAK3,PRMT8,ITGB1A,GABPB1,BCL2L2,SOX32,CA |
| protein homodimerization activity | ADD1,CADM3,LRP4,ZHX2,TYR,SYNDIG1,BMPR1A,TENM2,CHMP4A,ADRA2A |
| identical protein binding | G6PDX,POLG2,ENTPD2,LCP1,DCP1A,PSMD4,ATXN10,FAM108A1,TRIP13,SNCAIP |
| chaperone binding | DNAJB4,BAG2,HLA-B,VWF,DNAJB5,TBCE,DNAJA2L,TBCA,INS1,HES1 |
| heat shock protein binding | FKBP5,HSPA1A,APAF1,LMAN2,TPR,HSPA1L,DLST,DMPK,PPP5C,BAX |
| BH domain binding | BOK,BCL2L2,Bcl2a1b,BIK,BCL2A1A |
| ion channel binding | HOMER1,KCNC1,FAM115C,TCAP,KCND3,YWHAH,KCNIP2,PACS1A,PKD1,LRRK2 |
| metal ion binding | WT1A,PPM1F,MT2,NR2F1A,ZNF45,TRIM35-19,ZFP161,NUDT1,ARSI,FTR50 |
| protein binding | FAM122A,ORAI1,AOC3,SNX5,ENTPD1,ZBTB32,NUAK2,CKMT1,HMMR,ABCD3 |
Interacting Protein
BAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAK1.
MCL1;BCL2L1
Resources
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Research Area
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References
- Lauf, PK; Alqahtani, T; et al. Interaction between Na-K-ATPase and Bcl-2 proteins BclXL and Bak. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 308:C51-C60(2015).
- Jin, XH; Wu, XX; et al. Delineation of apoptotic genes for synergistic apoptosis of lexatumumab and anthracyclines in human renal cell carcinoma cells by polymerase chain reaction array. ANTI-CANCER DRUGS 23:445-454(2012).
