bace2
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  • Official Full Name
  • beta-site APP-cleaving enzyme 2
  • Background
  • This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimers disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  • Synonyms
  • BACE2; beta-site APP-cleaving enzyme 2; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; beta-secretase 2; memapsin-1; theta-secretase; aspartyl protease 1; 56 kDa aspartic-like protease; Down syndrome region aspartic protease; transmembrane aspartic proteinase Asp1; membrane-associated aspartic protease 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2;
Cat.#:BACE2-33MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse BACE2 Protein, His-Tagged
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Cat.#:Bace2-527MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Beta-Site APP-Cleaving Enzyme 2, His-tagged
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Cat.#:BACE2-10121HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BACE2, GST-tagged
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Cat.#:BACE2-1831HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BACE2 protein, His-tagged
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Cat.#:BACE2-578THTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human BACE2, GST-tagged
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Cat.#:BACE2-579HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BACE2 protein, MYC/DDK-tagged
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Cat.#:BACE2-579THTag:HIS
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human BACE2, His-tagged
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Cat.#:Bace2-1832MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Bace2 protein, His & GST-tagged
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Cat.#:Bace2-1833RTag:His|GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Bace2 protein, His & GST-tagged
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Cat.#:BACE2-930RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BACE2 Protein
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Cat.#:BACE2-1388MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse BACE2 cell lysate
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Involved Pathway

Bace2 involved in several pathways and played different roles in them. We selected most pathways Bace2 participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with Bace2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alzheimers disease
NCSTN; NDUFA11; NDUFA3; ATP2A2; COX6B2; ATF6; UQCR10; GRIN2C; COX7C; BID

Protein Function

Bace2 has several biochemical functions, for example, aspartic-type endopeptidase activity, beta-amyloid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Bace2 itself. We selected most functions Bace2 had, and list some proteins which have the same functions with Bace2. You can find most of the proteins on our site.
Function
Related Protein
Function aspartic-type endopeptidase activity
Related Protein PSEN2; CNTNAP5A; BACE2; REN; ANK2B; NAPSA; NOTS; SPPL3; PGA5; PGC
Function beta-amyloid binding
Related Protein HSD17B10; TGFB2; BACE1; APBB2; LDLRAD3; Apba1; APBB1; APBA3; ITM2C; CLSTN1