c1qa
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  • Official Full Name
  • complement component 1, q subcomponent, alpha polypeptide
  • Background
  • C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
  • Synonyms
  • C1QA; complement component 1, q subcomponent, alpha polypeptide; C1q; AI255395; complement C1q subcomponent subunit A;
Cat.#:C1QA-1345MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse C1QA Protein (23-245 aa), His-tagged
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Cat.#:C1QA-10475HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C1QA, GST-tagged
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Cat.#:C1QA-4292HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Complement Component 1, q Subcomponent, A Chain
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Cat.#:C1QA-925HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C1QA Protein, His-tagged
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Cat.#:C1QA-2560MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse C1QA Protein
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Cat.#:C1qa-7932MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse C1qa protein, His & T7-tagged
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Cat.#:C1QA-1041RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat C1QA Protein
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Cat.#:C1qa-7933RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat C1qa protein, His & T7-tagged
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Cat.#:C1QA-2722ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish C1QA
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Cat.#:C1QA-26126THTag:
Source (Host):Species:Human
Product nameNative Human C1QA
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Cat.#:C1QA-8143HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human C1QA 293 Cell Lysate
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Involved Pathway

C1QA involved in several pathways and played different roles in them. We selected most pathways C1QA participated on our site, such as Complement and coagulation cascades, Prion diseases, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C1QA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
F10; SERPINC1; C5AR1; GM5077; F8; F5; C1R; CR1L; FGA; C1RA
Prion diseases
PRKACA; C8G; NCAM2; STIP1; CASP12; BAX; C8A; HSPA5; C6; PRKACG
Pertussis
PYCARD; NLRP3; C1R; C3; NOS2; CALML5; CASP7; RELA; MAPK1; C1QA
Chagas disease (American trypanosomiasis)
MAPK12; RELA; IFNG; SERPINE1; IL6; IFNGR2; PPP2R2B; IKBKB; PPP2R2A; FASLG
Staphylococcus aureus infection
HLA-DPA1; C5AR1; C3; FCGR2B; C1RA; HLA-DPB1; C2; FCAR; HLA-DRB3; ICAM1
Systemic lupus erythematosus
CD28; C3; HLA-DQA2; HIST1H4M; HIST1H2BB; H3F3B; GM14477; HIST1H2AG; HLA-DRA; ACTN3

Protein Function

C1QA has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by C1QA itself. We selected most functions C1QA had, and list some proteins which have the same functions with C1QA. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein RECQL4; SNCA; HGS; NRAP; ALOX12B; APOBEC3G; SUPT5H; YAP1; TRP63; PTCRA

Interacting Protein

C1QA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1QA here. Most of them are supplied by our site. Hope this information will be useful for your research of C1QA.
C1QB; C1QC; LRP1; SGTA; PIAS2; PPP1CC; BAG6; PPP1CA; SLC25A47; GNPNAT1; HIPK3; q9k5j5_bacan; UBQLN2; UBQLN1; APOA1

C1QA Related Articles

Yuan, HY; Chen, R; et al. Crystallization and preliminary crystallographic studies of the complement 1qA globular domain from zebrafish, Dare-C1qAgD. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 70:911-914(2014).
Trouw, LA; Daha, N; et al. Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 173:76-83(2013).