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Recombinant human C1QA protein, His-tagged

Cat.No. : C1QA-926H
Product Overview : Recombinant C1QA protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
  • Specification
  • Gene Information
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Description : This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants.
Source : E.coli
Species : Human
Tag : His
Form : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Molecular Mass : 30 kDa
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : C1QA
Official Symbol : C1QA
Synonyms : C1QA
Gene ID : 712
mRNA Refseq : NM_015991.4
Protein Refseq : NP_057075.1
MIM : 120550
UniProt ID : P02745

Products Types

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C1QA-699R Recombinant Rat C1QA Protein, His (Fc)-Avi-tagged +Inquiry
C1QA-2528H Recombinant Human C1QA protein(23-245 aa), C-His-tagged +Inquiry
C1QA-1345M Recombinant Mouse C1QA Protein (23-245 aa), His-tagged +Inquiry
C1QA-333H Recombinant Human C1QA Protein, His-tagged +Inquiry

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◆ Native Protein
C1QA-26126TH Native Human C1QA +Inquiry

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◆ Lysates
C1QA-8143HCL Recombinant Human C1QA 293 Cell Lysate +Inquiry

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Related Gene

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does C1QA play in the clearance of apoptotic cells? 01/23/2022

It plays a role in recognizing and promoting the removal of apoptotic cells.

What therapeutic strategies are being explored involving C1QA modulation? 07/08/2021

Strategies are being explored to modulate C1QA activity in conditions like lupus and rheumatoid arthritis.

Are there known genetic mutations in C1QA associated with specific health conditions? 03/15/2021

Genetic deficiencies in C1QA are linked to increased susceptibility to infections and autoimmune conditions.

In which immune responses is C1QA critically involved? 03/01/2021

C1QA is involved in immune responses against pathogens and in the clearance of immune complexes.

How is C1QA implicated in autoimmune diseases? 06/27/2020

Dysregulation of C1QA can contribute to impaired clearance of immune complexes, leading to autoimmune diseases.

How does C1QA contribute to the activation of the complement system? 02/09/2020

It binds to antibodies or C-reactive protein on pathogen surfaces, activating C1r and C1s in the C1 complex.

What is the primary function of C1QA in the immune system? 08/27/2019

C1QA is a vital component of the C1 complex, initiating the classical complement pathway.

Customer Reviews (3)

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Reviews
01/23/2022

    Excellent quality, fast delivery.

    03/01/2021

      Reliable in experiments, quality.

      02/09/2020

        Product met all requirements.

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