CD5 Protein, CD5 molecule

CD5

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CD5

Official Full Name CD5 molecule
Background CD5 is a 67kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most thymocytes and B lymphocytes subset (B-1a lymphocytes) and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lamda light chains. It is expressed on approximately 10% of normal human peripheral blood cells and approximately 60% of splenic lymphocytes. It is not expressed on granulocytes, monocytes or T cells as defined by CD3 expression. CD19 defines a pan B antigen which is expressed from the earliest stages of B progenitor development, but is lost on terminal differentiation to plasma cells. It may also be present on some early myeloid progenitors, particularly those of the monoblastic type. The CD19 antigen is expressed on approximately 12% of peripheral blood lymphocytes. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen.
Synonyms CD5; CD5 molecule; CD5 antigen (p56 62) , LEU1; T-cell surface glycoprotein CD5; T1; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1; LEU1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • DDK
    • His
    • Fc
    • GST
    • HlgG1 Fc
    • Myc
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD5-1093H Recombinant Human CD5 Protein (Met1-Pro372), HlgG1 Fc-tagged HEK293 HlgG1 Fc
    Human CD5-0830H Recombinant Human CD5 Protein, GST-Tagged Wheat Germ GST
    Human CD5-135H Recombinant Human CD5 protein, His-tagged Insect Cell His
    Human CD5-146H Recombinant Human CD5, His-tagged E.coli His
    Human CD5-175H Recombinant Human CD5 protein, His-tagged HEK293 His
    Human CD5-2222H Recombinant Human CD5, His tagged Human Cell His
    Human CD5-235H Recombinant Human CD5, StrepII-tagged Human Cell Strep II
    Human CD5-2572HCL Recombinant Human CD5 cell lysate Human Cell N/A
    Human CD5-26633TH Recombinant Human CD5 Wheat Germ N/A
    Human CD5-3098H Recombinant Human CD5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CD5-830H Recombinant Human CD5 Protein, DDK/His-tagged HEK293 DDK/His
    Mouse Cd5-2277M Recombinant Mouse Cd5, His tagged Human Cell His
    Mouse CD5-2498MCL Recombinant Mouse CD5 cell lysate Human Cell N/A
    Rat CD5-1257R Recombinant Rat CD5 Protein Mammalian Cell His
    Rat CD5-1293RCL Recombinant Rat CD5 cell lysate Human Cell N/A
    Rat Cd5-8795R Recombinant Rat Cd5, Fc tagged Human Cell Fc
    Rat Cd5-8796R Recombinant Rat Cd5, His tagged Human Cell His
    Rat Cd5-8797R Recombinant Rat Cd5, Fc-tagged Human Cell Fc
    Chicken CD5-6483C Recombinant Chicken CD5 Mammalian Cell His

    CD5 involved in several pathways and played different roles in them. We selected most pathways CD5 participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hematopoietic cell lineage CD1D2; IL7; GP1BB; HLA-DRB5; IL9R; CD33; CD1C; ITGA2; IL5RA; CD7

    CD5 has several biochemical functions, for example, protein binding, receptor activity, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD5 itself. We selected most functions CD5 had, and list some proteins which have the same functions with CD5. You can find most of the proteins on our site.

    Function Related Protein
    protein binding NRIP1; STX6; NEURL1B; SLC30A1; PKHD1L1; MYO6; PIPOX; SKI; NACC2; DOK4
    receptor activity TLR3; LILRB2; FOLR1; GRIA3B; VMN1R43; PVRL3; GRIN2A; OGFRL1; NLGN4A; CUBN
    scavenger receptor activity TINAGL1; ENDOU; TMPRSS4B; LGALS3BPB; POLR1B; MARCO; TMPRSS13B; TMPRSS15; PRG4; ENPP1
    transmembrane signaling receptor activity SPN; GP1BB; TLR7; EDAR; CLEC2D; LGR4; TLR5; OR103-4; TLR2-2; OR4C13

    CD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD5.

    PIK3R1; CD72; RASA1

    Kostopoulos, IV; Paterakis, G; et al. Immunophenotypic Analysis Reveals Heterogeneity and Common Biologic Aspects in Monoclonal B-Cell Lymphocytosis. GENES CHROMOSOMES & CANCER 54:210-221(2015).
    Antosz, H; Wojciechowska, K; et al. IL-6, IL-10, c-Jun and STAT3 expression in B-CLL. BLOOD CELLS MOLECULES AND DISEASES 54:258-265(2015).

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