cryab
Share
  • Official Full Name
  • crystallin, alpha B
  • Background
  • Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the;major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens;central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout;life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma;families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided;into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting;peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B,;for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat;shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature;proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates.;Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40;subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha;crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene;products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed;widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a;missense mutation cosegregated in a family with a desmin-related myopathy.
  • Synonyms
  • CRYAB; crystallin, alpha B; CRYA2; alpha-crystallin B chain; HSPB5; heat shock protein beta-5; rosenthal fiber component; heat-shock 20 kD like-protein; renal carcinoma antigen NY-REN-27; CTPP2
Cat.#:CRYAB-1926HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CRYAB Protein, GST-tagged
+Inquiry
Cat.#:CRYAB-185HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CRYAB
+Inquiry
Cat.#:CRYAB-27293THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRYAB
+Inquiry
Cat.#:CRYAB-310HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Crystallin Alpha B
+Inquiry
Cat.#:CRYAB-31725THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRYAB, His-tagged
+Inquiry
Cat.#:CRYAB-9158HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRYAB protein
+Inquiry
Cat.#:CRYAB-3934MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CRYAB Protein
+Inquiry
Cat.#:CRYAB-1610RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CRYAB Protein
+Inquiry
Cat.#:CRYAB-422CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CRYAB Protein, His-tagged
+Inquiry
Cat.#:CRYAB-1037RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CRYAB Protein, His-tagged
+Inquiry
Cat.#:CRYAB-6731CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CRYAB
+Inquiry
Cat.#:Cryab-330MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Crystallin, Alpha B
+Inquiry
Cat.#:CRYAB-7266HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CRYAB 293 Cell Lysate
+Inquiry

Involved Pathway

CRYAB involved in several pathways and played different roles in them. We selected most pathways CRYAB participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRYAB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
SEC61G; CALRL2; SEC63; DNAJC5; NFE2L2A; DNAJB1A; MAN1A1; NSFL1C; SAR1AB; CKAP4

Protein Function

CRYAB has several biochemical functions, for example, identical protein binding, metal ion binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRYAB itself. We selected most functions CRYAB had, and list some proteins which have the same functions with CRYAB. You can find most of the proteins on our site.
Function
Related Protein
Function identical protein binding
Related Protein ZNF703; COL1A2; AGXT2L1; GRASP; PIK3AP1; TRIP10; ERN1; SMN1; SDCBP; SMAD1
Function metal ion binding
Related Protein ZNF672; ITGB1BP3; DNAJA3; DNAJC21; ADH1; KAT8; PRUNE; SUMF2; ATP1A1A.3; KITA
Function microtubule binding
Related Protein NEFH; GAPDH; KIF14; FTCD; KIF7; CAMSAP1A; TRAF3IP1; MAP2; KIF9; MAST2
Function protein binding
Related Protein ORM1; LBR; FTL; RBM4; RMND5A; POLDIP3; TUBB; HDAC5; TRPC4; NGF
Function protein homodimerization activity
Related Protein UGT1A1; PAFAH1B2; CLIC6; S100B; RPL7; RIPK2; ERBB4; AGR2; C6orf108; GPD1A
Function structural constituent of eye lens
Related Protein ASL2; LIM2.3; CRYABB; ASL1; CPOX; CRYBB3; LIM2.4; CRYBA1; LIM2.1; CRYGD
Function unfolded protein binding
Related Protein SIL1; PFDN2; DNAJA2; DNAJB1; DNAJA3A; NDUFAF1; CCT5; DNAJB1B; NAP1L4; PFDN5

Interacting Protein

CRYAB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRYAB here. Most of them are supplied by our site. Hope this information will be useful for your research of CRYAB.
CRYAA; HSPB1; CRYGC

CRYAB Related Articles

Davidov, T; Nagar, M; et al. Carbonic anhydrase 4 and crystallin alpha-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology. JOURNAL OF SURGICAL RESEARCH 190:565-574(2014).
Campbell-Lloyd, AJM; Mundy, J; et al. Is Alpha-B Crystallin an Independent Marker for Prognosis in Lung Cancer?. HEART LUNG AND CIRCULATION 22:759-766(2013).