cx3cr1
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  • Official Full Name
  • chemokine (C-X3-C motif) receptor 1
  • Background
  • Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
  • Synonyms
  • CX3CR1; chemokine (C-X3-C motif) receptor 1; V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1; CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1;
Cat.#:CX3CR1-2150HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CX3CR1 Protein, GST-tagged
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Cat.#:CX3CR1-28062THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CX3CR1
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Cat.#:CX3CR1-1684RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CX3CR1 Protein
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Cat.#:CX3CR1-1103RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CX3CR1 Protein, His-tagged
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Cat.#:CX3CR1-7173HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CX3CR1 293 Cell Lysate
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Involved Pathway

CX3CR1 involved in several pathways and played different roles in them. We selected most pathways CX3CR1 participated on our site, such as Chemokine receptors bind chemokines, Chemokine signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CX3CR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine receptors bind chemokines
CCL35.2; CXCL13; CCR5; AMCF-II; CCRL2; CCR1; ACKR4; CCL19A.2; CCR7; CCL27
Chemokine signaling pathway
ARRB2; GNG8; PPBP; CCL13; CXCL1; CCL2; JAK3; SRC; CCL19; CCL23
Class A/1 (Rhodopsin-like receptors)
CCL19A.2; CCK; PENK; TAC3; PENKA; NMU; ADORA1; GPR4; FPR-RS3; LPAR1
Cytokine-cytokine receptor interaction
IL21R; TGFBR1A; KITLG; PRL; KIT; CCL28; IL6; EDAR; IL7R; IL29
GPCR ligand binding
GPR31B; QRFP; ADORA3; SST1.1; UTS2D; PTHLH; OPN1MW2; CHRM1; GPR132; TAC1
GPCRs, Class A Rhodopsin-like
OPN1SW; GPR12; CHRM4; OR10A5; OPN1MW; GPR20; OPN1LW; CNR1; GPR45; GPR65
Peptide GPCRs
SSTR5; SSTR4; CX3CR1; SSTR1; TAC4; CXCR6
Peptide ligand-binding receptors
CCBP2; INSL5; CCL35.2; TAC1; PYYA; CCL35.1; SSTR5; KISS1; ACKR4; RLN2

Protein Function

CX3CR1 has several biochemical functions, for example, C-X3-C chemokine receptor activity, chemokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CX3CR1 itself. We selected most functions CX3CR1 had, and list some proteins which have the same functions with CX3CR1. You can find most of the proteins on our site.
Function
Related Protein
Function C-X3-C chemokine receptor activity
Related Protein CX3CR1
Function chemokine receptor activity
Related Protein CCR6; CCR6A; CXCR3.2; RGRA; XCR1; CCR9; CCR3; CCR8; CMKLR1; CCBP2
Function protein binding
Related Protein ASH2L; NF2; SSRP1; GDNF; TSTD2; ATF4; MAP3K1; ITGB1BP2; CCDC117; SDHB

CX3CR1 Related Articles

Sugaya, M; et al. Chemokines and Skin Diseases. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 63:109-115(2015).
Bian, C; Zhao, ZQ; et al. Involvement of CX3CL1/CX3CR1 Signaling in Spinal Long Term Potentiation. PLOS ONE 10:-(2015).

CX3CR1 Related Gene Family

GPCRs