Recombinant Human CX3CR1 Protein, GST-tagged

• Cat.No.: CX3CR1-2150H
• Product Overview: Human CX3CR1 full-length ORF ( AAH28078.1, 1 a.a. - 355 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 64.79 kDa
• AA Sequence: MDQFPESVTENFEYDDLAEACYIGD IVVFGTVFLSIFYSVIFAIGLVGNL LVVFALTNSKKPKSVTDIYLLNLAL SDLLFVATLPFWTHYLINEKGLHNA MCKFTTAFFFIGFFGSIFFITVISI DRYLAIVLAANSMNNRTVQHGVTIS LGVWAAAILVAAPQFMFTKQKENEC LGDYPEVLQEIWPVLRNVETNFLGF LLPLLIMSYCYFRIIQTLFSCKNHK KAKAIKLILLVVIVFFLFWTPYNVM IFLETLKLYDFFPSCDMRKDLRLAL SVTETVAFSHCCLNPLIYAFAGEKF RRYLYHLYGKCLAVLCGRSVHVDFS SSESQRSRHGSVLSSNFTYHTSDGD ALLLL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CX3CR1 chemokine (C-X3-C motif) receptor 1 [ Homo sapiens ]
• Official Symbol: CX3CR1
• Synonyms: CX3CR1; chemokine (C-X3-C motif) receptor 1; chemokine (C X3 C) receptor 1 , CMKBRL1, GPR13; CX3C chemokine receptor 1; CCRL1; CMKDR1; V28; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1; GPR13; GPRV28; CMKBRL1
• Gene ID: 1524
• mRNA Refseq: NM_001171171
• Protein Refseq: NP_001164642
• MIM: 601470
• UniProt ID: P49238

Reviews

09/06/2016

The manufacturer's commitment to meeting regulatory requirements demonstrated its dedication to ethical research practices.

04/21/2016

The reliability of the product's quality and effectiveness from one batch to another instilled confidence in its usage.

02/08/2016

The product's adherence to regulatory standards aligned with our lab's commitment to responsible and transparent research.

Q&As

Are there therapeutic implications or potential targets related to CX3CR1 in immune-related disorders?

There are potential therapeutic implications related to CX3CR1 in immune-related disorders, making it a target of interest for drug development.

How does CX3CR1 contribute to the regulation of immune responses and cell migration?

CX3CR1 contributes to the regulation of immune responses and cell migration by responding to its ligand, fractalkine (CX3CL1).

In which immune cells is CX3CR1 predominantly expressed?

CX3CR1 is predominantly expressed in certain immune cells, including monocytes, macrophages, and certain subsets of T cells.

How does CX3CR1 influence the balance between immune tolerance and inflammation?

CX3CR1 plays a role in influencing the balance between immune tolerance and inflammation through its impact on immune cell function.

What diseases or conditions are associated with dysregulation or abnormal expression of CX3CR1?

Dysregulation or abnormal expression of CX3CR1 is associated with conditions such as atherosclerosis, neuroinflammatory disorders, and certain cancers.

Are there specific chemokines that bind to CX3CR1, and what is their role in immune modulation?

The ligand for CX3CR1, fractalkine (CX3CL1), is involved in immune modulation, influencing cell adhesion and migration.

What is the primary function of C-X3-C motif chemokine receptor 1 (CX3CR1) in the immune system?

C-X3-C motif chemokine receptor 1 (CX3CR1) primarily functions in the immune system, playing a role in immune responses and cell migration.