CX3CR1 Antibody-coupled magnetic MicroBeads

• Cat.No.: CX3CR1-9543M

Specification

• Species: Human
• Capacity: for 1×10^9 total cells
• Background: CX3CR1 is a transmembrane chemokine receptor with a molecular mass of 40 kDa. It binds the chemokine CX3CL1, also known as fractalkine or neurotactin. Binding of CX3CR1 to the membrane-bound form of fractalkine promotes cell-cell adhesion, whereas the soluble form induces cell migration of CX3CR1-expressing cells such as monocytes, NK cells, T cells, dendritic cells (DCs), and macrophages including microglia. CX3CR1 also plays an important role in the formation of transepithelial dendrites by intestinal DCs. Failure in the fractalkine/CX3CR1 interaction may contribute to the development of several inflammatory diseases including atherosclerosis, psoriasis, rheumatoid arthritis, and experimental autoimmune myositis.
• Application: Positive selection of CX3CR1-positive cells, e.g., after depleting cells of undesired lineage.