clec7a
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  • Official Full Name
  • C-type lectin domain family 7, member A
  • Background
  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded;glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a;cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition;receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this;way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms,;have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the;natural killer gene complex region.
  • Synonyms
  • CLEC7A; C-type lectin domain family 7, member A; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12 , CLECSF12; C-type lectin domain family 7 member A; dectin 1; hDectin 1; Beta GR; BGR; C type calcium dependent carbohydrate recognition domain lectin superfamily member 12; C type lectin domain family 7 member a; CLEC7A protein; Clecsf12; DECTIN 1 receptor; Dectin1; Dendritic cell associated C type lectin 1; Lectin like receptor 1; Putative transmembrane protein dectin 1; dectin-1; OTTHUMP00000164964; OTTHUMP00000164965; OTTHUMP00000164966; OTTHUMP00000233744; OTTHUMP00000233745; OTTHUMP00000233746; OTTHUMP00000233748; OTTHUMP00000233749; beta-glucan receptor; lectin-like receptor 1; DC-associat; CANDF4
Cat.#:CLEC7A-1473HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CLEC7A Protein, GST-tagged
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Cat.#:CLEC7A-11322HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CLEC7A, His-tagged
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Cat.#:CLEC7A-260HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLEC7A
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Cat.#:CLEC7A-261HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLEC7A, Fc-tagged
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Cat.#:CLEC7A-746HTag:His
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human CLEC7A Protein, His-tagged
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Cat.#:Clec7a-2204MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Clec7a, His tagged
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Cat.#:CLEC7A-1793RTag:N/A
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey CLEC7A Protein
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Cat.#:CLEC7A-907RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CLEC7A Protein, His-tagged
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Cat.#:CLEC7A-001HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLEC7A cell lysate
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Cat.#:CLEC7A-760HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLEC7A cell lysate
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Cat.#:CLEC7A-2455MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CLEC7A cell lysate
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Involved Pathway

Clec7a involved in several pathways and played different roles in them. We selected most pathways Clec7a participated on our site, such as Phagosome, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Clec7a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
BLB2; HBL4; CD209B; NOX1; CTSLA; THBS4; FCGR2C; TUBA3E; LAMP2; HLA-DRB3
Tuberculosis
BCL10; Cd209g; HLA-DRB5; LBP; MAPK10; BAX; FCER1G; VDR; ATP6V0A1; SPHK2

Protein Function

Clec7a has several biochemical functions, for example, (1->3)-beta-D-glucan binding, (1->3)-beta-D-glucan receptor activity, MHC protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Clec7a itself. We selected most functions Clec7a had, and list some proteins which have the same functions with Clec7a. You can find most of the proteins on our site.
Function
Related Protein
Function (1->3)-beta-D-glucan binding
Related Protein CLEC7A; PTX3; CD209B
Function (1->3)-beta-D-glucan receptor activity
Related Protein CLEC7A
Function MHC protein binding
Related Protein TRGV3; CLEC7A; MARCH1
Function carbohydrate binding
Related Protein CLEC4A2; KLRB1; SI; GCKR; ACAN; ASGR2; ZG16; HBL4; CLEC5A; PYGM
Function metal ion binding
Related Protein UNK; RORCA; C1GALT1A; ARSG; TKTL2; GUCA1E; CYGB2; NRXN3; SCRT2; MMP23BB
Function opsonin binding
Related Protein CLEC7A; Itgam&Itgb2; ITGAM
Function protein binding
Related Protein SLC30A8; PSMD9; TUBB2B; ASGR2; ZGPAT; DUSP23; CEP55; YAP1; UBE2E2; LILRB4
Function signaling pattern recognition receptor activity
Related Protein MARCO; TLR2; TRIM5; CLEC7A; DMBT1; COLEC12; FCN1

Interacting Protein

Clec7a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Clec7a here. Most of them are supplied by our site. Hope this information will be useful for your research of Clec7a.
BNIP3L; SYNE4; PTTG1IP; IL1RL1; BNIP3