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Clec7a

  • Official Full Name

    C-type lectin domain family 7, member A

  • Overview

    This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded;glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a;cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition;receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this;way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms,;have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the;natural killer gene complex region.
  • Synonyms

    CLEC7A; C-type lectin domain family 7, member A; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12 , CLECSF12; C-type lectin domain family 7 member A; dectin 1; hDectin 1; Beta GR; BGR; C type calcium dependent carbohydrate recognition domain lectin superfamily member 12; C type lectin domain family 7 member a; CLEC7A protein; Clecsf12; DECTIN 1 receptor; Dectin1; Dendritic cell associated C type lectin 1; Lectin like receptor 1; Putative transmembrane protein dectin 1; dectin-1; OTTHUMP00000164964; OTTHUMP00000164965; OTTHUMP00000164966; OTTHUMP00000233744; OTTHUMP00000233745; OTTHUMP00000233746; OTTHUMP00000233748; OTTHUMP00000233749; beta-glucan receptor; lectin-like receptor 1; DC-associat; CANDF4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Rhesus monkey
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • mFc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLEC7A-746H Active Recombinant Human CLEC7A Protein, His-tagged Mammalian cells His Thr66-Met201
Human CLEC7A-11322H Recombinant Human CLEC7A, His-tagged E.coli His 1-77a.a.
Human CLEC7A-260H Recombinant Human CLEC7A Human Cell N/A Thr66-Met201
Human CLEC7A-261H Recombinant Human CLEC7A, Fc-tagged Human Cell Fc Thr66-Met201
Human CLEC7A-1473H Recombinant Human CLEC7A Protein, GST-tagged Wheat Germ GST
Human CLEC7A-760HCL Recombinant Human CLEC7A cell lysate Human Cell N/A
Human CLEC7A-001HCL Recombinant Human CLEC7A cell lysate Human Cell N/A
Human CLEC7A-262H Recombinant Human CLEC7A protein (Thr66-Met201), mFc-tagged HEK293 mFc
Human CLEC7A-0624H Recombinant Human CLEC7A Protein (T66-M247), His tagged E.coli His T66-M247
Human CLEC7A-2172HF Recombinant Full Length Human CLEC7A Protein, GST-tagged In Vitro Cell Free System GST 77 amino acids
Human CLEC7A-2686H Recombinant Human CLEC7A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CLEC7A-130H Recombinant Human CLEC7A Protein, C-His-tagged E.coli C-His
Human CLEC7A-0623H Recombinant Human CLEC7A Protein (T66-M247), Flag tagged E.coli Flag T66-M247
Human CLEC7A-131H Recombinant Human CLEC7A Protein, His-tagged E.coli His
Human CLEC7A-2686H-B Recombinant Human CLEC7A Protein Pre-coupled Magnetic Beads HEK293
Mouse Clec7a-2204M Recombinant Mouse Clec7a protein(Phe69-Leu244), His-tagged HEK293 N-His Phe69-Leu244
Mouse CLEC7A-2455MCL Recombinant Mouse CLEC7A cell lysate Human Cell N/A
Mouse Clec7a-798M Recombinant Mouse Clec7a Protein, His-tagged E.coli N-His Arg71-Leu244
Rhesus monkey CLEC7A-1793R Recombinant Rhesus Monkey CLEC7A Protein HEK293 N/A
Rhesus Macaque CLEC7A-907R Recombinant Rhesus monkey CLEC7A Protein, His-tagged Mammalian Cell His
Rhesus Macaque CLEC7A-732R-B Recombinant Rhesus Macaque CLEC7A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CLEC7A-732R Recombinant Rhesus Macaque CLEC7A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Clec7a involved in several pathways and played different roles in them. We selected most pathways Clec7a participated on our site, such as Phagosome, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Clec7a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeTUBA1C;CD14;CANX;MHC1UXA2;HLA-E;BLB1;TLR2;RAB7;MSR1
TuberculosisHSPA9;BAX;IFNA16;RELA;HLA-DPA1;SPHK1;IFNA7;IL18;CALM1

Clec7a has several biochemical functions, for example, (1->3)-beta-D-glucan binding, (1->3)-beta-D-glucan receptor activity, MHC protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Clec7a itself. We selected most functions Clec7a had, and list some proteins which have the same functions with Clec7a. You can find most of the proteins on our site.

Function Related Protein
(1->3)-beta-D-glucan bindingCLEC7A;CD209B;PTX3
(1->3)-beta-D-glucan receptor activity
MHC protein bindingMARCH1;CLEC7A;TRGV3
carbohydrate bindingC15orf24;REG1A;KLRB1A;REG3G;LGALSLB;GALNTL1;MAN2C1;Siglece;LGALS2B
metal ion bindingZHX1;BMP1A;Fcer2a;HMOX2;NDUFS7;INO80B;PDE6B;TROVE2;AMDHD1
opsonin bindingCLEC7A;ITGAM;Itgam&Itgb2
protein bindingNR5A1;WIBG;MYH10;CAMK2A;RGS17;AKR1B10;AQP5;BAI3;MYL6B
signaling pattern recognition receptor activityCLEC7A;FCN1;COLEC12;TRIM5;TLR2;DMBT1;MARCO

Clec7a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Clec7a here. Most of them are supplied by our site. Hope this information will be useful for your research of Clec7a.

BNIP3L; SYNE4; PTTG1IP; IL1RL1; BNIP3

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