ctsb
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  • Official Full Name
  • cathepsin B
  • Background
  • Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. In humans, it is coded by the CTSB gene. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • CTSB; cathepsin B; EC 3.4.22.1; CPSB; amyloid precursor protein secretase; Cathepsin B1; cysteine protease; APPS; EC 3.4.22; APP secretase; OTTHUMP00000116009; OTTHUMP00000229510; OTTHUMP00000229511; OTTHUMP00000229512; OTTHUMP00000229514; OTTHUMP00000229515; OTTHUMP00000229516
Cat.#:CTSB-2099HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CTSB Protein, GST-tagged
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Cat.#:CTSB-3369HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTSB Protein, MYC/DDK-tagged
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Cat.#:CTSB-385HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTSB protein, His-tagged
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Cat.#:CTSB-169HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human CTSB protein, His-tagged
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Cat.#:CTSB-26410THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTSB, His-tagged
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Cat.#:CTSB-278HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTSB, His tagged
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Cat.#:Ctsb-28MTag:His
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Ctsb Protein, His-tagged
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Cat.#:Ctsb-413MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Cathepsin B
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Cat.#:Ctsb-415MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ctsb protein, His-tagged
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Cat.#:Ctsb-8176MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ctsb protein, His-tagged
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Cat.#:Ctsb-8331MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Ctsb
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Cat.#:Ctsb-1121RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Ctsb Protein, His-tagged
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Cat.#:Ctsb-8177RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ctsb protein, His-tagged
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Cat.#:CTSB-427CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CTSB Protein, His-tagged
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Cat.#:CTSB-1086RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CTSB Protein, His-tagged
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Cat.#:CTSB-416RTag:His
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus CTSB protein, His-tagged
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Cat.#:CTSB-6923CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CTSB
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Cat.#:CTSB-26408THTag:N/A
Source (Host):Species:Human
Product nameNative Human CTSB
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Cat.#:CTSB-5328HTag:N/A
Source (Host):Human liverSpecies:Human
Product nameNative Human Cathepsin B
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Cat.#:CTSB-188BTag:N/A
Source (Host):Species:Bovine
Product nameNative Bovine Cathepsin B
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Cat.#:CTSB-3025HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTSB cell lysate
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Cat.#:CTSB-1885MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CTSB cell lysate
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Cat.#:Kit-2366Tag:N/A
Source (Host):Species:
Product nameCathepsin B (CTSB) Inhibitor Screening Kit (Fluorometric)
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Involved Pathway

Ctsb involved in several pathways and played different roles in them. We selected most pathways Ctsb participated on our site, such as Adaptive Immune System, Antigen processing and presentation, Assembly of collagen fibrils and other multimeric structures, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ctsb were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
LILRB2; SPSB4; SPSB1; RAP1GAP2B; UBE2L6; CD300E; THEM4; RNF4; TREML1; MALT1
Antigen processing and presentation
RFXAP; IFNG; CTSL1; PSME2; KIR2DL4; HLA-A; CTSS; HLA-DRB5; KIR2DL1; HLA-DMB
Assembly of collagen fibrils and other multimeric structures
COL5A3A; COL11A1B; COL4A4; COL5A3B; PCOLCE; BMP1; TLL1; COL10A1A; DST; MMP13
Collagen degradation
MMP12; EMID2; MMP8; ELANE; COL25A1; CTSL1; CTSK; COL9A3; MMP15; MMP13
Collagen formation
LOXL4; CTSL1; SERPINH1B; LOX; LOXL2; COL28A1; DST; COL28A1A; TLL2; COL6A3
Degradation of the extracellular matrix
COL17A1; CTSG; FURINB; COL9A1; TIMP2B; TLL2; FURINA; CAPNS1; CTSL2; CTSD
Extracellular matrix organization
MMP24; LTBP3; CMA1; BMP10; COL15A1B; CEACAM8; TPSAB1; DAG1; COL16A1; SERPINH1A
Immune System
TRIM10; SIGIRR; RNF182; PAG1; WWP1; LILRA1; FCN3; SEC24A; GAN; DEFB129

Protein Function

Ctsb has several biochemical functions, for example, collagen binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ctsb itself. We selected most functions Ctsb had, and list some proteins which have the same functions with Ctsb. You can find most of the proteins on our site.
Function
Related Protein
Function collagen binding
Related Protein GPR56; COMP; SMAD3; USH2A; RELL2; HSD17B12; ITGA3; SERPINH1A; DDR2; SERPINH1B
Function cysteine-type endopeptidase activity
Related Protein CTSC; USP27X; MALT1A; ATG4D; UCHL1; CTSB; CTSL1B; USP9; ATG4A; CTSLA
Function cysteine-type peptidase activity
Related Protein CASP8; UFSP2; DESI1; DUB1; FAM49BA; CTSSB.1; USP9; CLCA3; CAPN2B; USP2A
Function kininogen binding
Related Protein CTSB; C1QBP; CTSL2; Ctsl
Function peptidase activity
Related Protein EGFBP2; HTRA1A; TMPRSS4B; CASP8; TMPRSS13A; USP25; PAPPAB; PRSS42; BAP1; NAPSA
Function peptide binding
Related Protein ANPEP; QRFPR; FNTB; TRHDE; ERAP1; NPFFR1L1; PPYR1; GNRHR; AVPR1A; CRIP1
Function protein binding
Related Protein ZFP335; ATP1B1; MAPK8IP3; CHMP1B; ALDOC; GAPDHS; UNC45B; SH3YL1; CGA; DDIT4L
Function protein self-association
Related Protein CNTN2; CTSC; LDB1; ZSWIM2; RSAD2; NKX3; CCDC88C; SLC2A1; TRP53; CCL5
Function proteoglycan binding
Related Protein CTSS; CTSL1; CTSB; SLIT2; CECR1; THBS1; COL5A1; CTSK; FCN2; NID1

Interacting Protein

Ctsb has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ctsb here. Most of them are supplied by our site. Hope this information will be useful for your research of Ctsb.
AMBP; MLH1; RGS2; ADAMTSL4; gag-pol; CSTA; SPHK1