Recombinant Human CTSB protein, His-tagged
Cat.No. : | CTSB-385H |
Product Overview : | Recombinant Human CTSB protein (Arg18-Ile339), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | Cathepsin B (CTSB) is also known as APP secretase (APPS) and CPSB, is an enzymatic protein belonging to the peptidase C1 family. Cathepsin B/CTSB is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme. The catalytic activity of Cathepsin B/ APPS contains: Hydrolysis of proteins with broad specificity for peptide bonds; Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L); In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. As a thiol protease, cathepsin B/CPSB is believed to participate in intracellular degradation and turnover of proteins and has also been implicated in tumor invasion and metastasis. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized from 0.22 um filtered solution in 50 mM Tris, 150 mM NaCl, pH8.0, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 36.7 kDa (pro-form) and 29.0 kDa (mature-form). Due to glycosylation, The reducing (R) protein migrates as 42-50 kDa (pro-form) band in SDS-PAGE and there may be a 34 kDa (mature-form) band. |
Protein length : | 322 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | CTSB |
Official Symbol : | CTSB |
Synonyms : | CTSB; cathepsin B; cathepsin B1; APP secretase; cysteine protease; amyloid precursor protein secretase; APPS; CPSB |
Gene ID : | 1508 |
mRNA Refseq : | NM_001908 |
Protein Refseq : | NP_001899 |
MIM : | 116810 |
UniProt ID : | P07858 |
Products Types
◆ Recombinant Protein | ||
Ctsb-2367M | Recombinant Mouse Ctsb Protein, Myc/DDK-tagged | +Inquiry |
Ctsb-10530M | Recombinant Mouse Ctsb Protein, His (Fc)-Avi-tagged | +Inquiry |
CTSB-2750H | Recombinant Human CTSB Protein, His (Fc)-Avi-tagged | +Inquiry |
CTSB-3369H | Recombinant Human CTSB Protein, MYC/DDK-tagged | +Inquiry |
CTSB-785H | Recombinant Human CTSB Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
CTSB-188B | Active Native Bovine Cathepsin B | +Inquiry |
CTSB-5328H | Native Human Cathepsin B | +Inquiry |
CTSB-26408TH | Native Human CTSB | +Inquiry |
◆ Lysates | ||
CTSB-3025HCL | Recombinant Human CTSB cell lysate | +Inquiry |
CTSB-1885MCL | Recombinant Mouse CTSB cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-2366 | Cathepsin B (CTSB) Inhibitor Screening Kit (Fluorometric) | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket