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Recombinant Mouse Ctsb Protein, His-tagged

Cat.No. : Ctsb-28M
Product Overview : Recombinant mouse CTSB, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
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Description : CTSB, also known as cathepsin B preproprotein, is a papain-family cysteine protease that is normally located in lysosomes. It has the ability to degrade several extracellular matrix components at both neutral and acidic pH and has been implicated in the progression of several human and rodent tumors progression and arthritis.
Source : Insect cells
Species : Mouse
Tag : His tag
Form : Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
Molecular Mass : 36.4kDa (330aa)28-40kDa (SDS-PAGE under reducing conditions)
AA Sequence : HDKPSFHPLS DDLINYINKQ NTTWQAGRNF YNVDISYLKK LCGTVLGGPK LPGRVAFGED IDLPETFDAR EQWSNCPTIG QIRDQGSCGSCWAFGAVEAI SDRTCIHTNG RVNVEVSAED LLTCCGIQCG DGCNGGYPSG AWSFWTKKGL VSGGVYNSHV GCLPYTIPPC EHHVNGSRPPCTGEGDTPRC NKSCEAGYSP SYKEDKHFGY TSYSVSNSVK EIMAEIYKNG PVEGAFTVFS DFLTYKSGVY KHEAGDMMGG HAIRILGWGV ENGVPYWLAA NSWNLDWGDN GFFKILRGEN HCGIESEIVA GIPRTDQYWG RFLEHHHHHH
Endotoxin : < 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity : >90% by SDS - PAGE
Storage : Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20Centigrade or -70Centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.5mg/ml (determined by Absorbance at 280nm)
Gene Name : Ctsb cathepsin B [ Mus musculus ]
Official Symbol : Ctsb
Synonyms : CTSB; cathepsin B; cathepsin B1; CB;
Gene ID : 13030
mRNA Refseq : NM_007798
Protein Refseq : NP_031824
MIM :
UniProt ID :
Pathway : Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; thyroid hormone biosynthesis, conserved biosystem;
Function : cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; hydrolase activity; kininogen binding; peptidase activity; peptide binding; protein complex binding; protein self-association;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does CTSB affect extracellular matrix remodeling in conditions like osteoarthritis? 01/28/2022

CTSB affects extracellular matrix remodeling, relevant in joint diseases like osteoarthritis.

What role does CTSB play in the pathology of neurodegenerative diseases, such as Alzheimer's? 03/29/2020

CTSB is implicated in neurodegenerative diseases, potentially contributing to protein aggregation and neuronal damage.

How do alterations in CTSB expression or activity affect tissue repair and fibrosis? 04/26/2019

Variations in CTSB expression impact tissue repair processes and the development of fibrosis in various organs.

What are the mechanisms by which CTSB modulates apoptosis and cell survival? 09/26/2018

CTSB regulates apoptosis and cell survival, influencing cell fate decisions under stress or damage.

How does CTSB influence the tumor microenvironment and cancer progression? 08/16/2018

CTSB can influence cancer progression by modulating the tumor microenvironment and facilitating tumor cell invasion.

How does CTSB (Cathepsin B) contribute to protein degradation and lysosomal function? 04/01/2018

CTSB is involved in lysosomal protein degradation, essential for cellular waste disposal and recycling.

What is the impact of CTSB in inflammatory responses and immune cell activation? 01/04/2018

CTSB plays a role in inflammation, impacting immune cell function and inflammatory responses.

Customer Reviews (3)

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Reviews
08/08/2021

    Exceptional protein engineering services, our trusted research partner.

    07/13/2021

      Reliable protein crystallography, key for our structural biology research.

      11/15/2018

        Swift protein quantification, improves data reliability in our work.

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