dnase1
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  • Official Full Name
  • deoxyribonuclease I
  • Background
  • This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
  • Synonyms
  • DNASE1; deoxyribonuclease I; DNL1; deoxyribonuclease-1; Dornase alfa; Deoxyribonuclease 1; Deoxyribonuclease1; DeoxyribonucleaseI; DNASE 1; DNase I lysosomal; DNaseI; DNL 1; DRNI; FLJ38093; Human urine deoxyribonuclease I; DNase I, lysosomal
Cat.#:DNASE1-10HTag:N/A
Source (Host):CHO CellSpecies:Human
Product nameRecombinant Human DNASE1 protein
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Cat.#:DNASE1-2774HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DNASE1 Protein, GST-tagged
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Cat.#:DNASE1-711BTag:N/A
Source (Host):CHOSpecies:Bovine
Product nameRecombinant bovine DNASE1 Protein
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Cat.#:DNASE1-1227BTag:N/A
Source (Host):PancreasSpecies:Bovine
Product nameRecombinant Bovine Deoxyribonuclease I
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Cat.#:DNASE1-12094HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNASE1, GST-tagged
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Cat.#:DNASE1-1529HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNASE1 protein, His-tagged
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Cat.#:DNASE1-195HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human DNASE1
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Cat.#:DNASE1-207HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human DNASE1, His tagged
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Cat.#:DNASE1-775HTag:GST|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNASE1 Protein, GST-His-tagged
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Cat.#:DNASE1-4726MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DNASE1 Protein
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Cat.#:DNASE1-1917RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DNASE1 Protein
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Cat.#:IL6ST-144CTag:Fc|His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus DNASE1, Fc tagged
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Cat.#:IL6ST-145CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus DNASE1, His tagged
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Cat.#:DNASE1-7097CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DNASE1
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Cat.#:DNASE1-781ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DNASE1
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Cat.#:DNASE1-8333BTag:N/A
Source (Host):PancreasSpecies:Bovine
Product nameNative Bovine DNASE1
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Cat.#:DNASE1-866HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human DNASE1 cell lysate
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Cat.#:DNASE1-P001HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human DNASE1 therapeutic protein
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Cat.#:CMC04Tag:N/A
Source (Host):Species:
Product nameDNase I
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Protein Function

DNASE1 has several biochemical functions, for example, actin binding, deoxyribonuclease I activity, endodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNASE1 itself. We selected most functions DNASE1 had, and list some proteins which have the same functions with DNASE1. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein PARVAB; FHOD3; PARVAA; EPS8; ABLIM3; SPTB; MYLK; SPATA31; SMYHC1; SNTB1
Function deoxyribonuclease I activity
Related Protein DNASE1; DICER1
Function endodeoxyribonuclease activity
Related Protein DNASE1L3L; ERCC4; MBD4; RPS3; DNASE1L3; MRE11A; DNASE1; ERCC5; DNASE1L1; DNASE1L2
Function protein binding
Related Protein TXNL4A; C9orf78; INO80B; EXO1; ZSCAN10; KIFC3; MRPS9; CD1A; Il4ra; PTPRZ1

DNASE1 Related Articles

Vogel, B; Frantz, S; et al. Determination of DNase activity by degradation of ethidium bromide-DNA complexes using a fluorescence plate reader. ANALYTICAL BIOCHEMISTRY 471:73-79(2015).
Fragoulis, GE; Vakrakou, AG; et al. Impaired degradation and aberrant phagocytosis of necrotic cell debris in the peripheral blood of patients with primary Sjogren's syndrome. JOURNAL OF AUTOIMMUNITY 56:12-22(2015).