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F2

  • Official Full Name

    coagulation factor II (thrombin)

  • Overview

    Thrombin (activated Factor II [IIa]) is a coagulation protein that has many effects in the coagulation cascade. Thrombin is a serine protease (EC 3.4.21.5) that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions. Thrombin is in the form of alpha-thrombin tat is the immediate end product of prothrombin activation, two further thrombin products can be identified, beta- and gamma-thrombin. These are degraded form that may arise from autodigestion of a thrombin preparation.
  • Synonyms

    F2; coagulation factor II (thrombin); prothrombin; serine protease; prothrombin B-chain; PT; THPH1;

  • Recombinant Proteins
  • Native Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Bovine
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • Bovine Plasma
  • Cattle Blood
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human plasma
  • Human Plasma
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Mouse Plasma
  • Pig Blood
  • Plasma
  • Porcine
  • Porcine Blood
  • Procine Blood
  • rat plasma
  • Rat plasma
  • Wheat Germ
  • Yeast
  • C
  • His
  • Myc
  • DDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • SUMO
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human F2-1103H Active Recombinant Human F2 Protein, His-tagged Mammalian cells His Met1-Glu622
Human F2-305H Recombinant Human Coagulation Factor II (F2) protein, His-tagged HEK293 His 598
Human F2-698H Recombinant Human F2 protein, His & GST-tagged E.coli His/GST Ala44~Arg327 (Accession# P00734)
Human F2-170H Recombinant Human F2 E.coli N/A
Human F2-3610H Recombinant Human F2 Protein, GST-tagged Wheat Germ GST
Human F2-12619H Recombinant Human F2 Protein, His-tagged E.coli His Ala44~Arg198
Human F2-5285H Native Human Coagulation Factor II (thrombin) Human plasma N/A
Human F2-955H Recombinant Human F2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human F2-5399H Recombinant Human F2 protein, His-tagged Yeast His 44-622aa
Human Thrombin-8H Human Thrombin Reference standard N/A
Human F2-069H Recombinant Human F2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human F2-180H Antithrombin Reference standard N/A
Human F2-4495HF Recombinant Full Length Human F2 Protein, GST-tagged In Vitro Cell Free System GST 622 amino acids
Human F2-882H Recombinant Human F2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human F2-2877H Recombinant Human F2 protein, His-SUMO-tagged E.coli His-SUMO 44-622aa
Human F2-1882H Native Human Coagulation Factor II Human Plasma N/A
Human F2-490HFL Active Recombinant Full Length Human F2 Protein, C-Flag-tagged Mammalian cells Flag
Human F2-789H Recombinant Human F2 Protein HEK293 622
Human F2-882H-B Recombinant Human F2 Protein Pre-coupled Magnetic Beads HEK293
Human Prothrombin-60H Native Human Prothrombin Frag 2 N/A
Human F2-22H Human FEIBA Reference Standard(plasma derived) Reference standard N/A
Human F2-2425H Recombinant Human F2 Protein (Ala44-Arg327), N-His tagged E.coli N-His Ala44-Arg327
Human Prothrombin-59H Native Human Prothrombin Frag 1 N/A
Human F2-4095H Recombinant Human F2 Protein (Met1-Glu622), C-His tagged Mammalian cells C-His Met1-Glu622
Mouse Thrombin-31M Active Native Mouse Thrombin Plasma N/A
Mouse Thrombin-61M Active Native Mouse Thrombin N/A
Mouse F2-1186M Active Recombinant Mouse F2 protein(Met1-Gly618), His-tagged HEK293 C-His Met1-Gly618
Mouse F2-699M Recombinant Mouse F2 protein, His & T7-tagged E.coli His/T7 Ala44~Lys324 (Accession # P19221)
Mouse F2-7769M Recombinant Mouse F2 protein, His-tagged E.coli His Thr325~Gly618 (Accession # P19221)
Mouse F2-2124MCL Recombinant Mouse F2 cell lysate Human Cell N/A
Mouse F2-995M Recombinant Mouse F2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse F2-5287M Native Mouse Coagulation Factor II Mouse Plasma N/A
Rat F2-700R Recombinant Rat F2 protein, His-tagged E.coli His Ala44~Arg323
Rat F2-7770R Recombinant Rat F2 protein, His-tagged E.coli His Thr324~Arg617 (Accession # P18292)
Rat F2-5286R Native Rat Coagulation Factor II Rat plasma N/A
Rat F2-303R Native Rat Thrombin N/A
Rat F2-366R Recombinant Rat F2 Protein, His-tagged HEK293 His Met1-Arg617
Rat F2-1450R Recombinant Rat F2 Protein, His-tagged E.coli N-His Ser201-Arg323
Rat F2-73R Native Rat Prothrombin rat plasma N/A
Bovine F2-274B Active Native Bovine α-Thrombin Plasma N/A
Bovine Prothrombin-271B Active Native Bovine Prothrombin Frag 1 Plasma N/A
Bovine Prothrombin-270B Active Native Bovine Prothrombin Plasma N/A
Bovine F2-90B Active Native Bovine Thrombin Bovine Plasma N/A
Bovine F2-277B Active Native Bovine α-Thrombin-BFPRck (Biotin) Plasma N/A
Bovine F2-276B Active Native Bovine α-Thrombin-FPRck (FPR-CMK*) Plasma N/A
Bovine F2-275B Active Native Bovine α-Thrombin-DFP Plasma N/A
Bovine F2-5401B Native Bovine Coagulation Factor II (thrombin) Bovine Plasma N/A
Cattle Thrombin-21H Active Native Cattle Thrombin Cattle Blood N/A
Rhesus Macaque F2-1531R Recombinant Rhesus monkey F2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque F2-1356R Recombinant Rhesus Macaque F2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque F2-1356R-B Recombinant Rhesus Macaque F2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish F2-12566Z Recombinant Zebrafish F2 Mammalian Cell His
Pig Thrombin-20H Active Native Pig Thrombin Pig Blood N/A
Pig Thrombin-24P Recombinant Porcine Thrombin Porcine Blood N/A
Pig F2-647P Native Pig F2 Procine Blood N/A
Pig F2-907P Recombinant Pig F2 Protein, His-tagged E.coli N-His Ala44-Arg315
Pig F2-5402P Native Porcine Coagulation Factor II (thrombin) Porcine N/A
Chicken F2-6173C Recombinant Chicken F2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • F2 Related Articles
  • F2 Related Gene Family
  • F2 Related Research Area

F2 involved in several pathways and played different roles in them. We selected most pathways F2 participated on our site, such as Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with F2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionP2RX4A;GRIN1B;TAAR14A;CSH2;F2;GABRR3;GLP1R;PTGER1;P2RY14
Complement and coagulation cascadesC5;FGB;C5AR1;CR1L;PLG;C8B;TFPI;GM5077;LOC100514666
Regulation of actin cytoskeletonFGF13A;PDGFAA;PIK3R3B;PXN;ARHGEF4;ARHGEF7;FGF1B;TMSB;PIP4K2C

F2 has several biochemical functions, for example, calcium ion binding, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by F2 itself. We selected most functions F2 had, and list some proteins which have the same functions with F2. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingCDH6;EPD;PCDH15A;HPCAL4;VIL1;MYL12A;S100A9;FSTL5;PCDH1G11
growth factor activityAMBN;GSDF;LFT2;PDGFA;MDKA;CSF3;INHBE;FGF11;EPGN
protein bindingTHBD;ETS1;RAB2A;TNNI3;MYO1E;APEH;CTSK;CYB5R1;COBRA1
receptor bindingGRP;ACOX1;UTS2;GRIN2A;SRI;CCL17;REN;SLC27A2;TNFSF10
serine-type endopeptidase activityKLK13;CELA2B;DPP4;HABP2;MCPT8;PREP;KLK1B16;HTRA2;HP
thrombospondin receptor activitySDC4;CD47;F2

F2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F2 here. Most of them are supplied by our site. Hope this information will be useful for your research of F2.

q846v4_staau; anti-thrombin_mus_pe; C1QBP; THBD

Zhou, FF; Sun, RL; et al. Myostatin Gene Mutated Mice Induced with Tale Nucleases. ANIMAL BIOTECHNOLOGY 26:169-179(2015).
Roslaniec, L; Jurkov, AS; et al. Design of Single-Switch Inverters for Variable Resistance/Load Modulation Operation. IEEE TRANSACTIONS ON POWER ELECTRONICS 30:3200-3214(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can you discuss the role of the F2 gene in the synthesis of vitamin K-dependent clotting factors, and how disruptions in this process may lead to coagulation disorders? 04/10/2022

The F2 gene plays a crucial role in the synthesis of vitamin K-dependent clotting factors, including prothrombin. Disruptions in this process, often due to genetic or nutritional factors, can contribute to coagulation disorders, impacting hemostasis and blood clotting.

How is the F2 gene regulated at the transcriptional level, and what factors influence prothrombin synthesis in hepatocytes? 08/07/2021

Transcriptional regulation of the F2 gene involves factors like vitamin K-dependent gamma-carboxylation. Hepatocytes synthesize prothrombin under the influence of vitamin K and other coagulation factors.

The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation. 04/07/2020

The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation.

What are the implications of genetic variations in the F2 gene, particularly polymorphisms, on prothrombin function and susceptibility to thrombotic or bleeding disorders? 11/20/2019

Genetic variations in F2, including polymorphisms, can influence prothrombin function. Certain variants may predispose individuals to thrombotic or bleeding disorders.

How does genetic variation in the F2 gene impact prothrombin levels, and what are the consequences for an individual's risk of thrombotic events? 04/16/2018

Genetic variations in the F2 gene can influence prothrombin levels, affecting an individual's propensity for thrombotic events. Certain variants may predispose individuals to a higher or lower risk of abnormal blood clot formation.

Customer Reviews (3)

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Reviews
01/01/2022

    Quality control is evident. This product ensures accuracy in our studies.

    01/27/2019

      Our lab swears by this protein. Fast shipping is a definite bonus.

      12/18/2018

        Consistently reliable. The shipping speed is appreciated in our fast-paced lab.

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