f2
Share
  • Official Full Name
  • coagulation factor II (thrombin)
  • Background
  • Thrombin (activated Factor II [IIa]) is a coagulation protein that has many effects in the coagulation cascade. Thrombin is a serine protease (EC 3.4.21.5) that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions. Thrombin is in the form of alpha-thrombin tat is the immediate end product of prothrombin activation, two further thrombin products can be identified, beta- and gamma-thrombin. These are degraded form that may arise from autodigestion of a thrombin preparation.
  • Synonyms
  • F2; coagulation factor II (thrombin); prothrombin; serine protease; prothrombin B-chain; PT; THPH1
Cat.#:F2-366RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat F2 Protein, His-tagged
+Inquiry
Cat.#:F2-3610HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human F2 Protein, GST-tagged
+Inquiry
Cat.#:F2-955HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human F2 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:F2-1103HTag:His
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human F2 Protein, His-tagged
+Inquiry
Cat.#:F2-12619HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human F2, His-tagged
+Inquiry
Cat.#:F2-170HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human F2
+Inquiry
Cat.#:F2-305HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human F2 protein, His-tagged
+Inquiry
Cat.#:F2-698HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human F2 protein, His & GST-tagged
+Inquiry
Cat.#:F2-1186MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse F2, His tagged
+Inquiry
Cat.#:F2-699MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse F2 protein, His & T7-tagged
+Inquiry
Cat.#:F2-7769MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse F2 protein, His-tagged
+Inquiry
Cat.#:F2-700RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat F2 protein, His-tagged
+Inquiry
Cat.#:F2-7770RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat F2 protein, His-tagged
+Inquiry
Cat.#:F2-1531RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey F2 Protein, His-tagged
+Inquiry
Cat.#:F2-6173CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken F2
+Inquiry
Cat.#:F2-12566ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish F2
+Inquiry
Cat.#:Thrombin-24PTag:N/A
Source (Host):Porcine bloodSpecies:Pig
Product nameRecombinant Porcine Thrombin
+Inquiry
Cat.#:F2-1882HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Coagulation Factor II
+Inquiry
Cat.#:F2-5285HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Coagulation Factor II (thrombin)
+Inquiry
Cat.#:Prothrombin-59HTag:
Source (Host):Species:Human
Product nameNative Human Prothrombin Frag 1
+Inquiry
Cat.#:Prothrombin-60HTag:
Source (Host):Species:Human
Product nameNative Human Prothrombin Frag 2
+Inquiry
Cat.#:F2-5287MTag:N/A
Source (Host):Mouse plasmaSpecies:Mouse
Product nameNative Mouse Coagulation Factor II
+Inquiry
Cat.#:Thrombin-31MTag:
Source (Host):PlasmaSpecies:Mouse
Product nameNative Mouse Thrombin
+Inquiry
Cat.#:Thrombin-61MTag:
Source (Host):Species:Mouse
Product nameNative Mouse Thrombin
+Inquiry
Cat.#:F2-303RTag:
Source (Host):Species:Rat
Product nameNative Rat Thrombin
+Inquiry
Cat.#:F2-5286RTag:N/A
Source (Host):Rat plasmaSpecies:Rat
Product nameNative Rat Coagulation Factor II
+Inquiry
Cat.#:F2-73RTag:N/A
Source (Host):Species:Rat
Product nameNative Rat Prothrombin
+Inquiry
Cat.#:F2-274BTag:
Source (Host):Species:Bovine
Product nameNative Bovine α-Thrombin
+Inquiry
Cat.#:F2-275BTag:
Source (Host):Species:Bovine
Product nameNative Bovine α-Thrombin-DFP
+Inquiry
Cat.#:F2-276BTag:
Source (Host):Species:Bovine
Product nameNative Bovine α-Thrombin-FPRck (FPR-CMK*)
+Inquiry
Cat.#:F2-277BTag:
Source (Host):Species:Bovine
Product nameNative Bovine α-Thrombin-BFPRck (Biotin)
+Inquiry
Cat.#:F2-5401BTag:N/A
Source (Host):Bovine PlasmaSpecies:Bovine
Product nameNative Bovine Coagulation Factor II (thrombin)
+Inquiry
Cat.#:F2-90BTag:
Source (Host):Species:Bovine
Product nameNative Bovine Thrombin
+Inquiry
Cat.#:Prothrombin-270BTag:
Source (Host):Species:Bovine
Product nameNative Bovine Prothrombin
+Inquiry
Cat.#:Prothrombin-271BTag:
Source (Host):Species:Bovine
Product nameNative Bovine Prothrombin Frag 1
+Inquiry
Cat.#:F2-5402PTag:N/A
Source (Host):PorcineSpecies:Pig
Product nameNative Porcine Coagulation Factor II (thrombin)
+Inquiry
Cat.#:F2-647PTag:
Source (Host):Procine BloodSpecies:Pig
Product nameNative Pig F2
+Inquiry
Cat.#:Thrombin-20HTag:
Source (Host):Pig BloodSpecies:Pig
Product nameNative Pig Thrombin
+Inquiry
Cat.#:Thrombin-21HTag:
Source (Host):Cattle BloodSpecies:Cattle
Product nameNative Cattle Thrombin
+Inquiry
Cat.#:F2-2124MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse F2 cell lysate
+Inquiry
Cat.#:F2-180HTag:
Source (Host):Species:Human
Product nameAntithrombin Reference standard
+Inquiry
Cat.#:F2-22HTag:
Source (Host):Species:Human
Product nameHuman FEIBA Reference Standard(plasma derived) Reference standard
+Inquiry
Cat.#:Thrombin-8HTag:
Source (Host):Species:Human
Product nameHuman Thrombin Reference standard
+Inquiry

Involved Pathway

F2 involved in several pathways and played different roles in them. We selected most pathways F2 participated on our site, such as Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with F2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neuroactive ligand-receptor interaction
MTNR1BB; OPRD1; CHRNB3B; TAAR6; GABBR2; HTR1AA; DRD7; KISS1RA; MCHR1; GABRB3
Complement and coagulation cascades
F12; F13A1; TFPI; SERPINC1; CFH; PLG; BDKRB1; C1QB; C8A; PLAU
Regulation of actin cytoskeleton
CYFIP1; ARPC5A; MYH9; FGD; PXN; FGFR3; MYLPFB; INS; PPP1CB; APC2

Protein Function

F2 has several biochemical functions, for example, calcium ion binding, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by F2 itself. We selected most functions F2 had, and list some proteins which have the same functions with F2. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein CRB2B; DCHS1; PCDH7; EYS; PPEF1; SCUBE2; CAPN13; SULF1; PCDHA2; ANXA2A
Function growth factor activity
Related Protein BMP7; IGF2B; CNTF; INHBAB; CSF2; GDF7; ENDOU; GMFB; VEGFAB; THBS4
Function protein binding
Related Protein UBE2G2; ZFP64; PAEP; RIPK1L; SRI; RIPK3; GLRB; CROP; H2-KE2; TTN
Function receptor binding
Related Protein ZAP70; C5; PLG; C1QTNF2; HAND2; FGF12B; SMAGP; FGF13B; NSG1; SRMS
Function serine-type endopeptidase activity
Related Protein PRSS38; PRSS46; FAM108A1; KLK7; ST14A; TMPRSS4B; CFB; GZMF; KLK15; PRSS54
Function thrombospondin receptor activity
Related Protein SDC4; CD47; F2

Interacting Protein

F2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F2 here. Most of them are supplied by our site. Hope this information will be useful for your research of F2.
q846v4_staau; anti-thrombin_mus_pe; C1QBP; THBD

F2 Related Articles

Zhou, FF; Sun, RL; et al. Myostatin Gene Mutated Mice Induced with Tale Nucleases. ANIMAL BIOTECHNOLOGY 26:169-179(2015).
Roslaniec, L; Jurkov, AS; et al. Design of Single-Switch Inverters for Variable Resistance/Load Modulation Operation. IEEE TRANSACTIONS ON POWER ELECTRONICS 30:3200-3214(2015).

F2 Related Gene Family

TGF Cytokines