fyn
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  • Official Full Name
  • FYN oncogene related to SRC, FGR, YES
  • Background
  • This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase;that has been implicated in the control of cell growth. The protein associates with the p85 subunit of;phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants;encoding distinct isoforms exist.
  • Synonyms
  • FYN; FYN oncogene related to SRC, FGR, YES; tyrosine-protein kinase Fyn; MGC45350; SLK; SYN; src-like kinase; proto-oncogene Syn; c-syn protooncogene; proto-oncogene c-Fyn; src/yes-related novel; tyrosine kinase p59fyn(T); OKT3-induced calcium influx regu
Cat.#:FYN-4585HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human FYN Protein, GST/His-tagged
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Cat.#:FYN-4586HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FYN Protein, GST-tagged
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Cat.#:FYN-2128HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FYN Oncogene Related To SRC, FGR, YES, His-tagged
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Cat.#:FYN-1766HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FYN protein, His & T7-tagged
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Cat.#:FYN-217HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FYN Oncogene Related To SRC, FGR, YES
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Cat.#:FYN-2410HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FYN, GST-tagged
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Cat.#:FYN-28958THTag:
Source (Host):Species:Human
Product nameRecombinant Human FYN
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Cat.#:FYN-322HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FYN, GST-tagged, Active
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Cat.#:FYN-50HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human FYN protein, Flag-tagged, Biotinylated
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Cat.#:FYN-6112MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FYN Protein
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Cat.#:FYN-2427RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FYN Protein
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Cat.#:FYN-6901CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FYN
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Cat.#:FYN-6091HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FYN 293 Cell Lysate
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Involved Pathway

FYN involved in several pathways and played different roles in them. We selected most pathways FYN participated on our site, such as Sphingolipid signaling pathway, Phospholipase D signaling pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with FYN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Sphingolipid signaling pathway
PLCB1; LOC100328615; PIK3R3; PPP2R2A; PLD1; MAPK1; PRKCG; NRAS; MAPK3; ABCC1
Phospholipase D signaling pathway
PLA2G4A; PLCG2; PIK3R2; TSC1; RHOA; RAF1; GRM5; RALB; PIK3R1; PTGFR
Axon guidance
UNC5D; DNM2; AP2A2; DLG3; CAP2; IL17RD; L1CAM; EPHA4A; DCC; COL4A3
Osteoclast differentiation
TYROBP; LILRA4; CYBB; TREM2; FCGR2B; TNFRSF11B; NOX1; FHL2; IFNGR2; LCK
Focal adhesion
PIK3CA; MYLK2; CCND2A; Itga10&Itgb1; ITGB7; CHAD; GRB2A; CCND2; ITGB8; ITGB1
Adherens junction
ACTN4; RHOA; PTPN1; SRC; CTNNB1; SMAD4; EP300; SSX2IPA; VCLA; PTPRB
Platelet activation
ORAI1; GP1BA; COL24A1; STIM1; MAPK1; PPP1R12A; PTGIR; BTK; COL27A1; P2RX1
Natural killer cell mediated cytotoxicity
NCR1; TNFRSF10B; PTPN11; KIR2DS4; HRAS; IFNA10; NRAS; CD244; RAC2; NFATC2
T cell receptor signaling pathway
GRB2; NCK2; SHB; PIK3CD; MAPK1; MAPK9; PIK3R5; FYN; GRAPA; NFKB1
Fc epsilon RI signaling pathway
PRKCA; MAP2K3; FYN; RAC1; VAV2; NRAS; MAPK9; FCER1A; SOS1; PLCG1
Cholinergic synapse
GNGT2; PRKCB; PLCB4; GNG12; PRKCG; KCNQ5; PLCB1; GNG7; KCNJ12; PIK3R5
Prion diseases
CASP12; Hc; PRKACA; C8G; PRKACG; C1QB; ELK1; C1QC; C5; LAMC1
Pathogenic Escherichia coli infection
TUBB2A; CLDN1; ITGB1; TUBA1B; TUBA4A; HCLS1; TUBA1A; CTTN; TUBB6; YWHAZ
Measles
TNFAIP3; NFKBIB; IFNA4; MSN; SLAMF1; IFNA13; MAP3K7; IFNAR1; EIF2AK4; IL6
Viral myocarditis
HLA-DRB4; HLA-DRB5; MYH7; EIF4G2; FYN; H2-Q10; HLA-DPB1; HLA-C; HLA-DRA; SGCB

Protein Function

FYN has several biochemical functions, for example, ATP binding, CD4 receptor binding, CD8 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FYN itself. We selected most functions FYN had, and list some proteins which have the same functions with FYN. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein KIF20A; MCM3L; PKM; PRKCB; PTK7A; ABCG2C; CDC6; UBE2I; GUCY2E; PCXA
Function CD4 receptor binding
Related Protein PLSCR1; LCK; PLSCR4; FYN; SPG21
Function CD8 receptor binding
Related Protein FYN; LCK
Function G-protein coupled receptor binding
Related Protein RSPO3; GNA15; NPB; QRFP; DNAJA1; PROK1; ARRB2; GNAI2B; GNA11A; HSPA8
Function T cell receptor binding
Related Protein DOCK2; CD1d1; FYN; EPS8L1; H2-Q10; CD3G; HLA-A; CD3E
Function ephrin receptor binding
Related Protein CBL; EFNB3; FYN; GRB2; SIPA1L1; PTPN1; EFNA1; EPHA4; EFNA3B; CHN1
Function glycoprotein binding
Related Protein BBC3; VWF; Serpina1b; ERLEC1; AZGP1; CDH1; FGFR1; DNAJC5; FOXRED2; TFRC
Function growth factor receptor binding
Related Protein FYN; SRC; SLC9A3R1; APP
Function ion channel binding
Related Protein PKD2; AKAP9; AASS; KCNB2; SLC8A1; PACS1A; RYR2; CTNNB1; GPD1L; RIMS3
Function metal ion binding
Related Protein GFI1AB; ESRRGB; SIRT1; ZBTB49; FHL1B; NUDT19; ADAP1; ZFP541; MAT1A; ZNF512
Function non-membrane spanning protein tyrosine kinase activity
Related Protein JAK2; PRKCD; BAZ1B; ZAP70; FYN; LCK; WEE1; ABL2; MATK; FER
Function peptide hormone receptor binding
Related Protein NPPA; FYN; LEP; PTPN11; PTHLHA; PTH; PTHLH; ADCYAP1; NPPC; RUNDC3A
Function phosphatidylinositol 3-kinase binding
Related Protein IGF1R; DAB1; FYN; IGF1RA; BECN1; IRS2; IRS4; TYRO3; ATP1A1; LCK
Function protein binding
Related Protein NLRC4; AGR2; MITD1; STMN1; POU3F2; CENPW; DPEP1; TBX2A; PHF21A; SYT17
Function protein tyrosine kinase activity
Related Protein ALK; CSF1RA; DYRK3; MATK; CLK3; TNK1; DYRK2; MET; MAP3K9; KIT
Function tubulin binding
Related Protein TBCA; PARK2; LRRK2; TTLL4; STMN2A; DAG1; STMN2; TTLL6; AGBL4; AGTPBP1

Interacting Protein

FYN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FYN here. Most of them are supplied by our site. Hope this information will be useful for your research of FYN.
FYB; CBL; PRKCD; KHDRBS1

FYN Related Articles

Nisbet, RM; Polanco, JC; et al. Tau aggregation and its interplay with amyloid-beta. ACTA NEUROPATHOLOGICA 129:207-220(2015).
Gujral, TS; Chan, M; et al. A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis. CELL 159:844-856(2014).

FYN Related Gene Family

TGF