fyn
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  • Official Full Name
  • FYN oncogene related to SRC, FGR, YES
  • Background
  • This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase;that has been implicated in the control of cell growth. The protein associates with the p85 subunit of;phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants;encoding distinct isoforms exist.
  • Synonyms
  • FYN; FYN oncogene related to SRC, FGR, YES; tyrosine-protein kinase Fyn; MGC45350; SLK; SYN; src-like kinase; proto-oncogene Syn; c-syn protooncogene; proto-oncogene c-Fyn; src/yes-related novel; tyrosine kinase p59fyn(T); OKT3-induced calcium influx regu
Cat.#:FYN-4585HTag:GST|His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human FYN Protein, GST/His-tagged
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Cat.#:FYN-4586HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FYN Protein, GST-tagged
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Cat.#:FYN-2128HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FYN Oncogene Related To SRC, FGR, YES, His-tagged
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Cat.#:FYN-1766HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FYN protein, His & T7-tagged
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Cat.#:FYN-217HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FYN Oncogene Related To SRC, FGR, YES
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Cat.#:FYN-2410HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FYN, GST-tagged
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Cat.#:FYN-28958THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FYN
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Cat.#:FYN-322HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FYN, GST-tagged, Active
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Cat.#:FYN-50HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human FYN protein, Flag-tagged, Biotinylated
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Cat.#:FYN-6112MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FYN Protein
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Cat.#:FYN-2427RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FYN Protein
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Cat.#:FYN-6901CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FYN
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Cat.#:FYN-6091HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FYN 293 Cell Lysate
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Involved Pathway

FYN involved in several pathways and played different roles in them. We selected most pathways FYN participated on our site, such as Sphingolipid signaling pathway, Phospholipase D signaling pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with FYN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Sphingolipid signaling pathway
PDPK1; PPP2R5B; PIK3R1; BID; SPTLC3; ROCK1; PPP2R3A; RAC3; S1PR4; RELA
Phospholipase D signaling pathway
RRAS2; PLCG1; CXCR2; INS1; GNAS; AGPAT5; Kitl; GRB2; RRAS; MAPK1
Axon guidance
PEA15; SEMA3A; KALRNB; RAC3; CLASP1; SEMA4A; EPHB4B; ABL1; PAK6; CDC42
Osteoclast differentiation
PIK3CG; NOX1; IL1A; SIRP-BETA; PIK3R3; NCF4; NFKBIA; MAPK8; TAB2; FCGR2C
Focal adhesion
AASS; ACTB1; MYL2B; PIK3CG; PIK3R3B; COMP; ARHGAP5; PIK3CD; ROCK1; PRKCBB
Adherens junction
INSRA; LEF1; TCF7L2; EGFR; Fert2; BAIAP2A; CTNNA3; CDC42; PTPRM; RHOAC
Platelet activation
GNAQ; PIK3R1; COL24A1; F2RL3; FCGR2A; PIK3CD; FGA; MYL12B; PRKG2; TBXAS1
Natural killer cell mediated cytotoxicity
PAK1; NFATC1; SAMD3; Ifna11; RAC3; MAPK3; ITGB2; KLRC2; ULBP1; TNFRSF10D
T cell receptor signaling pathway
CBL; IFNG; TEC; PIK3CG; CD3E; CD3D; MAPK12; CD4; AKT1; PDPK1; VAV1
Fc epsilon RI signaling pathway
MAPK1; MAP2K6; PLA2G4A; MAPK3; LCP2; MAPK13; IL5; BTK; MAP2K1; PLCG2
Cholinergic synapse
GNG7; CHRNA7; GNG2; HRAS; CHRNA3; CAMK4; GNG12; ITPR1; CREB5; PLCB2
Prion diseases
C1QA; C7; NCAM2; CASP12; LAMC1; PRKACG; PRKACA; C8B; SOD1; MAP2K2
Pathogenic Escherichia coli infection
RHOA; OCLN; CLDN1; TUBA1B; ARHGEF2; TLR4; TUBA3C; TUBA1C; FYN; TUBA4A
Measles
SH2D1A; PIK3CB; Fasl; IRF3; IL1B; NFKBIA; IRAK1; TP73; Ifna15; STAT1
Viral myocarditis
PRF1; ABL1; RAC1; EIF4G3; HLA-DRB1; FYN; ITGB2; HLA-DOB; CD28; RAC3

Protein Function

FYN has several biochemical functions, for example, ATP binding, CD4 receptor binding, CD8 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FYN itself. We selected most functions FYN had, and list some proteins which have the same functions with FYN. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ERN1; PSMC4; PDIK1L; ETNK1; DNAJA2L; CLK3; VWA8; ATP11A; OBSCN; YSK4
Function CD4 receptor binding
Related Protein FYN; SPG21; PLSCR4; PLSCR1; LCK
Function CD8 receptor binding
Related Protein FYN; LCK
Function G-protein coupled receptor binding
Related Protein GPRC5B; ADORA1; S1PR2; NMS; GNA15.4; GNAT2; PROK2; RSPO3; UTS2D; HSPA1B
Function T cell receptor binding
Related Protein HLA-A; DOCK2; CD3G; CD1d1; CD3E; H2-Q10; FYN; EPS8L1
Function ephrin receptor binding
Related Protein SIPA1L1; EFNA1A; EFNB3; SDCBP; EFNA2; EFNA5B; SHC1; ANKS1B; EFNA4; PTPN1
Function glycoprotein binding
Related Protein OS9; SDC1; LDLR; BBC3; TFR2; EDEM2; Shh; AZGP1; FGFR1; THBS1
Function growth factor receptor binding
Related Protein SRC; SLC9A3R1; APP; FYN
Function ion channel binding
Related Protein CALM; SNTA1; EPN1; ACTN1; BAK1; FAM115A; FYN; TRPC1; KCNQ3; PDE4B
Function metal ion binding
Related Protein CECR1A; ZC3H13; FOXP4; NEURL1B; ZNF706; ZFP280D; CYGB2; ZFP518A; Ar; ZBTB9
Function non-membrane spanning protein tyrosine kinase activity
Related Protein BMX; ABL1; PTK2BB; Fert2; FER; YRK; JAK1; PTK6B; SYK; ZNF143B
Function peptide hormone receptor binding
Related Protein PTH; JAK2; PTHLH; FYN; RUNDC3A; NPPA; LEP; NPPC; PTPN11; ADCYAP1
Function phosphatidylinositol 3-kinase binding
Related Protein IGF1R; INSR; CORO1A; IRS1; CALM1; IRS4; TYRO3; PIK3R1; LCK; FYN
Function protein binding
Related Protein FUCA2; EMID2; SERPINB5; NME4; HMOX2; GRB2; HIST1H4L; CCDC68; NIPSNAP1; MYOCD
Function protein tyrosine kinase activity
Related Protein FES; TESK2; WEE1; KDR; JAK2; FYNB; FGFR1B; MET; ALK; FER
Function tubulin binding
Related Protein LRRK2; TPR; TTLL4; EML1; CENPJ; AGBL1; CDK5RAP2; STMN2B; RABGAP1; STMN1A

Interacting Protein

FYN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FYN here. Most of them are supplied by our site. Hope this information will be useful for your research of FYN.
FYB; CBL; PRKCD; KHDRBS1

FYN Related Articles

Nisbet, RM; Polanco, JC; et al. Tau aggregation and its interplay with amyloid-beta. ACTA NEUROPATHOLOGICA 129:207-220(2015).
Gujral, TS; Chan, M; et al. A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis. CELL 159:844-856(2014).

FYN Related Gene Family

TGF