fzd7
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  • Official Full Name
  • frizzled class receptor 7
  • Background
  • Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
  • Synonyms
  • FZD7; frizzled class receptor 7; FzE3; frizzled-7; fz-7; hFz7; frizzled homolog 7; frizzled family receptor 7; Frizzled, drosophila, homolog of, 7; frizzled 7, seven transmembrane spanning receptor;
Cat.#:FZD7-2166HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FZD7 Protein, GST-tagged
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Cat.#:FZD7-4598HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FZD7 Protein, GST-tagged
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Cat.#:Fzd7-589MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Frizzled Homolog 7 (Drosophila), Fc-tagged
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Cat.#:FZD7-12HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FZD7 Protein, Fc-tagged
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Cat.#:FZD7-26288THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FZD7
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Cat.#:FZD7-537HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human FZD7 Protein, Fc-tagged
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Cat.#:FZD7-643HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human FZD7
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Cat.#:FZD7-6121MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FZD7 Protein
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Cat.#:FZD7-5794CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FZD7
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Cat.#:FZD7-6088HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FZD7 293 Cell Lysate
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Involved Pathway

FZD7 involved in several pathways and played different roles in them. We selected most pathways FZD7 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with FZD7 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
PRKACBA; WNT9A; RAC2; CACYBP; SFRP2; FZD8B; WNT4; FZD8A; WNT7A; NKD1
Hippo signaling pathway
LATS1; PRKCZ; PPP2R2D; AJUBA; WNT5B; CTNNA3; AFP; ACTB; SMAD4; TCF7L2
Signaling pathways regulating pluripotency of stem cells
SMARCAD1; SKIL; HNF1A; WNT5B; FZD5; PCGF5; ESX1; FZD3; WNT9B; RAF1
Melanogenesis
PRKCG; ASIP; PRKCBB; CAMK2G1; FZD2; GNAS; FZD1; FZD9; WNT9B; Kitl
HTLV-I infection
TCF3; XBP1; MAPK8; RRAS; TGFB1; PIK3R1; RELA; NFATC2; CD3E; CCNB2
Pathways in cancer
MITF; GNAI3; AXIN2; VEGFC; FGF14; ARHGEF12; BDKRB2; SOS1; FZD1; MAP2K2
Proteoglycans in cancer
CAMK2G; ARHGEF1; FGFR1; PDCD4; Casp3; GPC1; SOS1; MAPK13; FLNA; NANOG
Basal cell carcinoma
WNT2B; FZD8; WNT3A; FZD10; APC; DVL3; STK36; BMP2; FZD6; WNT9A

Protein Function

FZD7 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FZD7 itself. We selected most functions FZD7 had, and list some proteins which have the same functions with FZD7. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled receptor activity
Related Protein CMKLR1; OR5B2; CXCR6; RXFP2B; TAAR11; VMN2R116; MRGPRB5; OXTRL; VIPR1B; CXCR4
Function PDZ domain binding
Related Protein SLC9A3R2; GNG12; SLC22A12; LRP2; GRIK5; ADAM17; PTENB; KIDINS220; ACVR2A; DOCK4
Function Wnt-activated receptor activity
Related Protein FZD10; FZD7B; LRP6; FZD3; FZD2; FZD6; FZD7A; FZD9B; FZD8B; FZD7
Function Wnt-protein binding
Related Protein SETD6; FZD9; FZD3; FZD7; Fzd4; SFRP1B; FZD10; SFRP4; FZD3A; LRP6
Function frizzled binding
Related Protein WNT3A; CTHRC1; DVL1B; DVL1; WNT6; LRP6; WNT5B; WNT7B; MYOC; WNT1
Function protein binding
Related Protein LGALS3; KCNJ4; PIK3C3; YIF1A; TNFSF10; PIR; KANK2; PODXL2; NOS3; C7orf49

Interacting Protein

FZD7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FZD7 here. Most of them are supplied by our site. Hope this information will be useful for your research of FZD7.
SDCBP; WNT3; sdcbp; C1qa; UBQLN4; UBQLN1

FZD7 Related Articles

Yuan, K; Orcholski, ME; et al. Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis. AMERICAN JOURNAL OF PATHOLOGY 185:69-84(2015).
Ross, J; Busch, J; et al. A Rare Human Syndrome Provides Genetic Evidence that WNT Signaling Is Required for Reprogramming of Fibroblasts to Induced Pluripotent Stem Cells. CELL REPORTS 9:1770-1780(2014).

FZD7 Related Gene Family

GPCRs