Active Recombinant Mouse Frizzled Homolog 7 (Drosophila), Fc-tagged

• Cat.No.: Fzd7-589M
• Product Overview: RecombinantMouse Fzd7 protein was expressed in Murine myeloma cell line with the Fc partof Human IgG1 Pro100-Lys330 (C-terminus) and Mouse Frizzled-7 Gln33-Leu185(N-terminus).

Specification

• Species: Mouse
• Source: Mammalian Cells
• Tag: Fc
• Protein Length: 33-185 a.a.
• Description: Fzd7 is a member ofthe Frizzled family of unconventional G-protein-coupled glycoprotein receptorsfor the Wnt signaling pathway. The Wnt genes encode a large family ofglycoproteins that are essential in development and tissue maintenance.
• Form: Supplied as a 0.2 μmfiltered solution in PBS.
• N-terminal Sequence: Gln33 predicted
• Molecular Weight: 43 kDa
• Activity: Measured by itsability to bind biotinylated Wnt-5a in a functional ELISA with an estimated KD< 5 nM.
• Endotoxin Level: <1.0 EU per 1 μgof the protein by the LAL method.
• SDS-PAGE: 55-60 kDa, reducingconditions
• Purity: >95%, by SDS-PAGEunder reducing conditions and visualized by silver stain.
• Reconstitution: Reconstitute at 200μg/mL in sterile PBS.
• Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to-70 °C under sterile conditions after reconstitution.

Gene Information

• Gene Name: Fzd7 frizzled homolog 7(Drosophila) [ Mus musculus ]
• Official Symbol: Fzd7
• Synonyms: Fzd7;frizzled homolog 7 (Drosophila); Fz7; OTTHUMP00000022716; frizzled-7;Fz-7; mFz7
• Gene ID: 14369
• mRNA Refseq: NM_008057
• Protein Refseq: NP_032083
• UniProt ID: Q6P551
• Chromosome Location: 1
• Pathway: Basal cellcarcinoma; Class B/2 (Secretin family receptors); GPCR ligand binding; HTLV-Iinfection; Melanogenesis; Pathways in cancer; Signal Transduction; Signalingby GPCR; Wnt Signaling Pathway; Wnt signaling network
• Function: G-proteincoupled receptor activity; PDZ domain binding; Wnt-activated receptoractivity; Wnt-protein binding